{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Z"],"funding":["National Natural Science Foundation of China"],"pagination":["14561-14571"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7321986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(25)"],"pubmed_abstract":["Recombination between homeologous chromosomes, also known as homeologous exchange (HE), plays a significant role in shaping genome structure and gene expression in interspecific hybrids and allopolyploids of several plant species. However, the molecular mechanisms that govern HEs are not well understood. Here, we studied HE events in the progeny of a nascent allotetraploid (genome AADD) derived from two diploid progenitors of hexaploid bread wheat using cytological and whole-genome sequence analyses. In total, 37 HEs were identified and HE junctions were mapped precisely. HEs exhibit typical patterns of homologous recombination hotspots, being biased toward low-copy, subtelomeric regions of chromosome arms and showing association with known recombination hotspot motifs. But, strikingly, wh"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Homoeologous exchanges occur through intragenic recombination generating novel transcripts and proteins in wheat and other polyploids."],"pmcid":["PMC7321986"],"funding_grant_id":["NSFC #31830006"],"pubmed_authors":["Feldman M","Li J","Zhang Z","Xun H","Bian Y","Ma X","Gou X","Gong L","Liu B","Levy AA","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Homoeologous exchanges occur through intragenic recombination generating novel transcripts and proteins in wheat and other polyploids.","description":"Recombination between homeologous chromosomes, also known as homeologous exchange (HE), plays a significant role in shaping genome structure and gene expression in interspecific hybrids and allopolyploids of several plant species. However, the molecular mechanisms that govern HEs are not well understood. Here, we studied HE events in the progeny of a nascent allotetraploid (genome AADD) derived from two diploid progenitors of hexaploid bread wheat using cytological and whole-genome sequence analyses. In total, 37 HEs were identified and HE junctions were mapped precisely. HEs exhibit typical patterns of homologous recombination hotspots, being biased toward low-copy, subtelomeric regions of chromosome arms and showing association with known recombination hotspot motifs. But, strikingly, wh","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-05-03T00:15:12.11Z","creation":"2021-02-20T05:02:08Z"},"accession":"S-EPMC7321986","cross_references":{"pubmed":["32518116"],"doi":["10.1073/pnas.2003505117"]}}