biostudies-literatureSeimon RVParker Hughes BequestNational Heart, Lung, and Blood InstituteEndocrine Society of AustraliaRebecca L. Cooper Medical Research FoundationUniversity of Sydney/National Health and Medical Research Council of AustraliaNational Health and Medical Research Council of AustraliaSydney Medical School FoundationAustralian Government Department of Education and TrainingThe Frecker Family TrustSenior Research FellowshipsHeart Research InstituteUniversity of SydneyNational Health and Medical Research Council of Australia Early Career Research Fellowshipe04007https://www.ebi.ac.uk/biostudies/studies/S-EPMC7322133biostudies-literatureUnknown6(6)We have previously shown that a severely energy-restricted diet leads to greater loss of weight, fat, lean mass and bone mineral density (BMD) at 12 months in postmenopausal women with obesity than a moderately energy-restricted diet. We now aim to evaluate whether these effects are sustained longer term (ie, at 36 months). 101 postmenopausal women were randomized to either 12 months of moderate (25 to 35%) energy restriction with a food-based diet (moderate intervention), or 4 months of severe (65 to 75%) energy restriction with a total meal replacement diet followed by moderate energy restriction for 8 months (severe intervention). Body weight and composition were measured at 0, 24 and 36 months. Participants in the severe intervention lost ~1.5 to 1.7 times as much weight, waist circumfHeliyon3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial.PMC7322133102600511358971042555K24HL136321072771Lagopoulos JSainsbury AWild-Taylor ALFernando HAMcClintock SByrne NMGibson AASeimon RVFranklin JCenter JRGrieve SMHarper CJohnson NACaterson IDMarkovic TPLiu PYfalse3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial.We have previously shown that a severely energy-restricted diet leads to greater loss of weight, fat, lean mass and bone mineral density (BMD) at 12 months in postmenopausal women with obesity than a moderately energy-restricted diet. We now aim to evaluate whether these effects are sustained longer term (ie, at 36 months). 101 postmenopausal women were randomized to either 12 months of moderate (25 to 35%) energy restriction with a food-based diet (moderate intervention), or 4 months of severe (65 to 75%) energy restriction with a total meal replacement diet followed by moderate energy restriction for 8 months (severe intervention). Body weight and composition were measured at 0, 24 and 36 months. Participants in the severe intervention lost ~1.5 to 1.7 times as much weight, waist circumf2020-01-01T00:00:00Z2020 Jun2025-04-19T23:40:50.029Z2020-07-04T07:22:31ZS-EPMC73221333261309610.1016/j.heliyon.2020.e04007