biostudies-literatureUnknown11Rajan RMichael J. Fox Foundation for Parkinson's ResearchOver the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of genetic discoveries to other ethnically diverse populations are unknown. The Indian population has been under-represented in PD research. The Genetic Architecture of PD in India (GAP-India) project aims to develop one of the largest clinical/genomic bio-bank for PD in India. Specifically, GAP-India project aims to: (1) develop a pan-Indian deeply phenotyped clinical repository of Indian PD patients; (2) perform whole-genome sequencing in 500 PD samples to catalog Indian genetic variability and to develop an Indian PD map for the scientific community; (3) perforFrontiers in neurology524https://www.ebi.ac.uk/biostudies/studies/S-EPMC7323575biostudies-literatureGenetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research.PMC7323575Grover SSturm MDivya KPAgarwal PRamalingam SBhatt MGoyal VKumar NSreeram Prasad AVGasser TSatagopam VPSchwamborn JRiess OPal PKDesai SKishore AKumar SFerreira TRajan RMehta SWali GMYadav RKandadai RMChandak GRPrashanth LKKumar-Sreelatha AHannussek MShetty KBusskamp VBorgohain RBartusch FPandey SSharma MMadhusoodanan UKKruger JSeth PLichtner PKumar HWadia PRoeper JKruger RLux-GIANT ConsortiumfalseGenetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research.Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of genetic discoveries to other ethnically diverse populations are unknown. The Indian population has been under-represented in PD research. The Genetic Architecture of PD in India (GAP-India) project aims to develop one of the largest clinical/genomic bio-bank for PD in India. Specifically, GAP-India project aims to: (1) develop a pan-Indian deeply phenotyped clinical repository of Indian PD patients; (2) perform whole-genome sequencing in 500 PD samples to catalog Indian genetic variability and to develop an Indian PD map for the scientific community; (3) perfor2020-01-01T00:00:00Z20202026-04-30T03:52:56.599Z2020-11-20T08:53:27ZS-EPMC73235753265548110.3389/fneur.2020.00524