{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Matboli M"],"funding":["Ain Shams Faculty of Medicine"],"pagination":["46-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7324892"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Aim</h4>The aim of this study was to explore the expression of exosomal non-coding RNAs (ncRNAs) in the sera of patients with HCC <i>versus</i> control.<h4>Methods</h4>Firstly, Bioinformatics analysis was conducted to retrieve ncRNAs specific to HCC (hsa-miRNA-1298 and lncRNA-RP11-583F2.2). Afterwards, extraction and characterization of exosomes were performed. We measured the expression of the chosen exosomal RNAs by reverse transcriptase quantitative real-time PCR in sera of 60 patients with HCC, 42 patients with chronic hepatitis C (CHC) infection and 18 healthy normal volunteers.<h4>Results</h4>The exosomal ncRNAs [hsa-miRNA-1298, lncRNA-RP11-583F2.2] had better sensitivity and specificity than alpha-fetoprotein (AFP) in HCC diagnosis.<h4>Conclusion</h4>The exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis."],"journal":["Current genomics"],"pubmed_title":["Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepato-cellular Carcinoma."],"pmcid":["PMC7324892"],"funding_grant_id":["2016-36"],"pubmed_authors":["Ali-Labib R","Matboli M","Nasser HE","Habib EK","El-Tawdi AHF","Labib ME"],"additional_accession":[]},"is_claimable":false,"name":"Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepato-cellular Carcinoma.","description":"<h4>Aim</h4>The aim of this study was to explore the expression of exosomal non-coding RNAs (ncRNAs) in the sera of patients with HCC <i>versus</i> control.<h4>Methods</h4>Firstly, Bioinformatics analysis was conducted to retrieve ncRNAs specific to HCC (hsa-miRNA-1298 and lncRNA-RP11-583F2.2). Afterwards, extraction and characterization of exosomes were performed. We measured the expression of the chosen exosomal RNAs by reverse transcriptase quantitative real-time PCR in sera of 60 patients with HCC, 42 patients with chronic hepatitis C (CHC) infection and 18 healthy normal volunteers.<h4>Results</h4>The exosomal ncRNAs [hsa-miRNA-1298, lncRNA-RP11-583F2.2] had better sensitivity and specificity than alpha-fetoprotein (AFP) in HCC diagnosis.<h4>Conclusion</h4>The exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-04T13:38:27.549Z","creation":"2025-04-04T13:38:27.549Z"},"accession":"S-EPMC7324892","cross_references":{"pubmed":["32655298"],"doi":["10.2174/1389202920666191210111849"]}}