{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilde JH"],"funding":["National Institutes of Health","NIGMS NIH HHS"],"pagination":["8245-8252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7327504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["85(12)"],"pubmed_abstract":["Dihapto-coordinate 1,2-dihydropyridine complexes of the metal fragment {WTp(NO)(PMe<sub>3</sub>)} (Tp = tris(pyrazolyl)borate), derived from pyridine, are demonstrated to undergo protonation at C6 followed by regioselective amination at C5 with a variety of primary and secondary amines. The addition takes place stereoselectively <i>anti</i> to the metal center, producing exclusively <i>cis</i>-disubstituted products. The resulting 1,2,5,6-tetrahydropyridines can be successfully liberated by oxidation, providing a route to novel molecules of potential medicinal interest."],"journal":["The Journal of organic chemistry"],"pubmed_title":["A Highly Divergent Synthesis of 3-Aminotetrahydropyridines."],"pmcid":["PMC7327504"],"funding_grant_id":["R01 GM132205","1R01GM132205"],"pubmed_authors":["Dickie DA","Wilde JH","Harman WD"],"additional_accession":[]},"is_claimable":false,"name":"A Highly Divergent Synthesis of 3-Aminotetrahydropyridines.","description":"Dihapto-coordinate 1,2-dihydropyridine complexes of the metal fragment {WTp(NO)(PMe<sub>3</sub>)} (Tp = tris(pyrazolyl)borate), derived from pyridine, are demonstrated to undergo protonation at C6 followed by regioselective amination at C5 with a variety of primary and secondary amines. The addition takes place stereoselectively <i>anti</i> to the metal center, producing exclusively <i>cis</i>-disubstituted products. The resulting 1,2,5,6-tetrahydropyridines can be successfully liberated by oxidation, providing a route to novel molecules of potential medicinal interest.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-04T08:29:20.96Z","creation":"2020-07-05T07:08:17Z"},"accession":"S-EPMC7327504","cross_references":{"pubmed":["32434325"],"doi":["10.1021/acs.joc.0c00853"]}}