{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Perumal N"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["101597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7327981"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34"],"pubmed_abstract":["Ocular vascular dysfunction is a major contributing factor to the pathogenesis of glaucoma. In recent years, there has been a renewed interest in the role of angiotensin II (Ang II) in mediating the disease progression. Despite its (patho)physiological importance, the molecular mechanisms underlying Ang II-mediated oxidative stress remain largely unexplored in the ocular vasculature. Here, we provide the first direct evidence of the alterations of proteome and signalling pathways underlying Ang II-elicited oxidative insult independent of arterial pressure changes in the ophthalmic artery (OA) and retina (R) employing an in vitro experimental model. Both R and OA were isolated from male C57Bl/6J mice (n = 15/group; n = 5/biological replicate) and incubated overnight in medium containing eit"],"journal":["Redox biology"],"pubmed_title":["Bioenergetic shift and actin cytoskeleton remodelling as acute vascular adaptive mechanisms to angiotensin II in murine retina and ophthalmic artery."],"pmcid":["PMC7327981"],"funding_grant_id":["MA 8006/1-1"],"pubmed_authors":["Straßburger L","Grus FH","Manicam C","Pfeiffer N","Herzog DP","Perumal N","Muller MB"],"additional_accession":[]},"is_claimable":false,"name":"Bioenergetic shift and actin cytoskeleton remodelling as acute vascular adaptive mechanisms to angiotensin II in murine retina and ophthalmic artery.","description":"Ocular vascular dysfunction is a major contributing factor to the pathogenesis of glaucoma. In recent years, there has been a renewed interest in the role of angiotensin II (Ang II) in mediating the disease progression. Despite its (patho)physiological importance, the molecular mechanisms underlying Ang II-mediated oxidative stress remain largely unexplored in the ocular vasculature. Here, we provide the first direct evidence of the alterations of proteome and signalling pathways underlying Ang II-elicited oxidative insult independent of arterial pressure changes in the ophthalmic artery (OA) and retina (R) employing an in vitro experimental model. Both R and OA were isolated from male C57Bl/6J mice (n = 15/group; n = 5/biological replicate) and incubated overnight in medium containing eit","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-09T00:33:14.354Z","creation":"2020-07-10T07:18:59Z"},"accession":"S-EPMC7327981","cross_references":{"pubmed":["32513477"],"doi":["10.1016/j.redox.2020.101597"]}}