{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bacle A"],"funding":["European Regional Development Fund"],"pagination":["dmm043927"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7328154"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(6)"],"pubmed_abstract":["The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs an"],"journal":["Disease models & mechanisms"],"pubmed_title":["A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction."],"pmcid":["PMC7328154"],"funding_grant_id":["P-2016-BAFE28"],"pubmed_authors":["Sebille S","Faivre JF","Krzesiak A","Khoury S","Cognard C","Vandebrouck C","Contzler H","Ferreira T","Delpech N","Ferru-Clement R","Colas J","Bacle A","Bescond J","Kadri L"],"additional_accession":[]},"is_claimable":false,"name":"A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction.","description":"The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs an","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-05-31T23:09:52.18Z","creation":"2025-05-31T23:09:52.18Z"},"accession":"S-EPMC7328154","cross_references":{"pubmed":["32303571"],"doi":["10.1242/dmm.043927"]}}