biostudies-literatureBacle AEuropean Regional Development Funddmm043927https://www.ebi.ac.uk/biostudies/studies/S-EPMC7328154biostudies-literatureUnknown13(6)The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs anDisease models & mechanismsA comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction.PMC7328154P-2016-BAFE28Sebille SFaivre JFKrzesiak AKhoury SCognard CVandebrouck CContzler HFerreira TDelpech NFerru-Clement RColas JBacle ABescond JKadri LfalseA comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction.The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs an2020-01-01T00:00:00Z2020 Jun2025-05-31T23:09:52.18Z2025-05-31T23:09:52.18ZS-EPMC73281543230357110.1242/dmm.043927