{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Armstrong NM"],"funding":["NIA NIH HHS","NINR NIH HHS","National Institutes of Health","National Institute on Aging"],"pagination":["531-536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7328205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(3)"],"pubmed_abstract":["BACKGROUND:Depressive symptoms and hearing loss (HL) are independently associated with increased risk of incident disability; whether the increased risk is additive is unclear. METHODS:Cox Proportional Hazards models were used to assess joint associations of HL (normal, mild, moderate/severe) and late-life depressive symptoms (defined by a score of ≥8 on the 10-item Center for Epidemiologic Studies-Depression scale) with onset of mobility disability (a lot of difficulty or inability to walk ¼ mile and/or climb 10 steps) and any disability in activities of daily living (ADL), among 2,196 participants of the Health, Aging and Body Composition Study, a cohort of well-functioning older adults aged 70-79 years. Models were adjusted for age, race, sex, education, diabetes, hypertension, and body mass index. RESULTS:Relative to participants with normal hearing and without depressive symptoms, participants without depressive symptoms who had mild or moderate/severe HL had increased risk of incident mobility and ADL disability (hazard ratio [HR] for mobility disability, mild HL:1.34, 95% confidence interval [CI]: 1.09, 1.64 and HR for mobility disability, moderate/severe HL: 1.37, 95% CI: 1.08, 1.75 and HR for ADL disability, mild HL: 1.32, 95% CI: 1.08, 1.63, and HR for ADL disability, moderate/severe HL: 1.42, 95% CI: 1.11, 1.82). Among participants with depressive symptoms, mild HL (HR: 1.71, 95% CI: 1.09, 2.70) was associated with increased risk of incident mobility disability. CONCLUSIONS:Independent of depressive symptoms, risk of incident disability was greater in older adults with HL, regardless of severity. Further research into HL interventions may delay disability onset."],"journal":["The journals of gerontology. Series A, Biological sciences and medical sciences"],"pubmed_title":["Associations of Hearing Loss and Depressive Symptoms With Incident Disability in Older Adults: Health, Aging, and Body Composition Study."],"pmcid":["PMC7328205"],"funding_grant_id":["N01 AG062103","N01 AG062101","K01 AG054693","R01 AG028050","N01-AG-6-2106","R01 NR012459","N01 AG062106","N01-AG-6-2101","R01-AG028050","R01-NR012459","N01-AG-6-2103"],"pubmed_authors":["Kritchevsky S","Lin FR","Deal JA","Simonsick EM","Betz J","Harris T","Armstrong NM","Pratt S","Barry LC"],"additional_accession":[]},"is_claimable":false,"name":"Associations of Hearing Loss and Depressive Symptoms With Incident Disability in Older Adults: Health, Aging, and Body Composition Study.","description":"BACKGROUND:Depressive symptoms and hearing loss (HL) are independently associated with increased risk of incident disability; whether the increased risk is additive is unclear. METHODS:Cox Proportional Hazards models were used to assess joint associations of HL (normal, mild, moderate/severe) and late-life depressive symptoms (defined by a score of ≥8 on the 10-item Center for Epidemiologic Studies-Depression scale) with onset of mobility disability (a lot of difficulty or inability to walk ¼ mile and/or climb 10 steps) and any disability in activities of daily living (ADL), among 2,196 participants of the Health, Aging and Body Composition Study, a cohort of well-functioning older adults aged 70-79 years. Models were adjusted for age, race, sex, education, diabetes, hypertension, and body mass index. RESULTS:Relative to participants with normal hearing and without depressive symptoms, participants without depressive symptoms who had mild or moderate/severe HL had increased risk of incident mobility and ADL disability (hazard ratio [HR] for mobility disability, mild HL:1.34, 95% confidence interval [CI]: 1.09, 1.64 and HR for mobility disability, moderate/severe HL: 1.37, 95% CI: 1.08, 1.75 and HR for ADL disability, mild HL: 1.32, 95% CI: 1.08, 1.63, and HR for ADL disability, moderate/severe HL: 1.42, 95% CI: 1.11, 1.82). Among participants with depressive symptoms, mild HL (HR: 1.71, 95% CI: 1.09, 2.70) was associated with increased risk of incident mobility disability. CONCLUSIONS:Independent of depressive symptoms, risk of incident disability was greater in older adults with HL, regardless of severity. Further research into HL interventions may delay disability onset.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-21T16:54:05.849Z","creation":"2025-04-05T12:42:22.848Z"},"accession":"S-EPMC7328205","cross_references":{"pubmed":["30561511"],"doi":["10.1093/gerona/gly251"]}}