biostudies-literatureUnknown61(4)Del Giudice F<h4>Purpose</h4>Ongoing evidence has suggested the role of male factor infertility as a potential predictor of mortality and general health status. The aim of the present review is to update the current knowledge base regarding the association between male factor infertility and general health through a critical review of the literature.<h4>Materials and methods</h4>A systematic review of the literature was carried out from inception to November 2019 in order to evaluate significant associations between male infertility and adverse health outcomes such as cardiovascular, oncologic, metabolic and autoimmune diseases as well as overall mortality.<h4>Results</h4>In all, 27 studies met inclusion criteria and were critically examined. Five studies examined male infertility and cardiovascular diInvestigative and clinical urology355-371https://www.ebi.ac.uk/biostudies/studies/S-EPMC7329649biostudies-literatureClinical correlation among male infertility and overall male health: A systematic review of the literature.PMC7329649Belladelli FEisenberg MLDe Berardinis EFerro MSalonia AKasman AMDel Giudice FSciarra AfalseClinical correlation among male infertility and overall male health: A systematic review of the literature.<h4>Purpose</h4>Ongoing evidence has suggested the role of male factor infertility as a potential predictor of mortality and general health status. The aim of the present review is to update the current knowledge base regarding the association between male factor infertility and general health through a critical review of the literature.<h4>Materials and methods</h4>A systematic review of the literature was carried out from inception to November 2019 in order to evaluate significant associations between male infertility and adverse health outcomes such as cardiovascular, oncologic, metabolic and autoimmune diseases as well as overall mortality.<h4>Results</h4>In all, 27 studies met inclusion criteria and were critically examined. Five studies examined male infertility and cardiovascular di2020-01-01T00:00:00Z2020 Jul2025-04-04T13:25:49.294Z2025-04-04T13:25:49.294ZS-EPMC73296493266599210.4111/icu.2020.61.4.355