{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lex K"],"funding":["Howard Hughes Medical Institute","Fondation pour la Recherche Médicale","Ministry of Education and Science | Fundação para a Ciência e a Tecnologia"],"pagination":["15066-15074"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7334448"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(26)"],"pubmed_abstract":["Cancer incidence increases exponentially with age when human telomeres are shorter. Similarly, telomerase reverse transcriptase (<i>tert</i>) mutant zebrafish have premature short telomeres and anticipate cancer incidence to younger ages. However, because short telomeres constitute a road block to cell proliferation, telomere shortening is currently viewed as a tumor suppressor mechanism and should protect from cancer. This conundrum is not fully understood. In our current study, we report that telomere shortening promotes cancer in a noncell autonomous manner. Using zebrafish chimeras, we show increased incidence of invasive melanoma when wild-type (WT) tumors are generated in <i>tert</i> mutant zebrafish. Tissues adjacent to melanoma lesions (skin) and distant organs (intestine) in <i>te"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish."],"pmcid":["PMC7334448"],"funding_grant_id":["LISBOA-01-0145-FEDER-022170","SPF201809007006","SFRH/BD/52173/2013","PTDC/BIM-ONC/3402/2014","PTDC/SAU-ONC/116821/2010","IECS"],"pubmed_authors":["Maia Gil M","Giannetti K","Lex K","Lopes-Bastos B","Carvalho T","Marzullo M","Figueira M","Ferreira MG"],"additional_accession":[]},"is_claimable":false,"name":"Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish.","description":"Cancer incidence increases exponentially with age when human telomeres are shorter. Similarly, telomerase reverse transcriptase (<i>tert</i>) mutant zebrafish have premature short telomeres and anticipate cancer incidence to younger ages. However, because short telomeres constitute a road block to cell proliferation, telomere shortening is currently viewed as a tumor suppressor mechanism and should protect from cancer. This conundrum is not fully understood. In our current study, we report that telomere shortening promotes cancer in a noncell autonomous manner. Using zebrafish chimeras, we show increased incidence of invasive melanoma when wild-type (WT) tumors are generated in <i>tert</i> mutant zebrafish. Tissues adjacent to melanoma lesions (skin) and distant organs (intestine) in <i>te","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-07-15T23:26:14.993Z","creation":"2025-06-01T12:00:19.497Z"},"accession":"S-EPMC7334448","cross_references":{"pubmed":["32554492"],"doi":["10.1073/pnas.1920049117"]}}