{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ersche KD"],"funding":["Wellocme","Medical Research Council","National Institute for Health Research (NIHR)","RCUK | Medical Research Council","Wellcome Trust"],"pagination":["15253-15261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7334452"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(26)"],"pubmed_abstract":["Regular drug use can lead to addiction, but not everyone who takes drugs makes this transition. How exactly drugs of abuse interact with individual vulnerability is not fully understood, nor is it clear how individuals defy the risks associated with drugs or addiction vulnerability. We used resting-state functional MRI (fMRI) in 162 participants to characterize risk- and resilience-related changes in corticostriatal functional circuits in individuals exposed to stimulant drugs both with and without clinically diagnosed drug addiction, siblings of addicted individuals, and control volunteers. The likelihood of developing addiction, whether due to familial vulnerability or drug use, was associated with significant hypoconnectivity in orbitofrontal and ventromedial prefrontal cortical-striata"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Brain networks underlying vulnerability and resilience to drug addiction."],"pmcid":["PMC7334452"],"funding_grant_id":["105602/Z/14/Z","104631/z/14/z","NIHR200256","104631/Z/14/Z","G0701497","NF-SI-0513-10051","G0001354","G1000183","MC_G0802534"],"pubmed_authors":["Stochl J","Ersche KD","Meng C","Ziauddeen H","Williams GB","Robbins TW","Bullmore ET"],"additional_accession":[]},"is_claimable":false,"name":"Brain networks underlying vulnerability and resilience to drug addiction.","description":"Regular drug use can lead to addiction, but not everyone who takes drugs makes this transition. How exactly drugs of abuse interact with individual vulnerability is not fully understood, nor is it clear how individuals defy the risks associated with drugs or addiction vulnerability. We used resting-state functional MRI (fMRI) in 162 participants to characterize risk- and resilience-related changes in corticostriatal functional circuits in individuals exposed to stimulant drugs both with and without clinically diagnosed drug addiction, siblings of addicted individuals, and control volunteers. The likelihood of developing addiction, whether due to familial vulnerability or drug use, was associated with significant hypoconnectivity in orbitofrontal and ventromedial prefrontal cortical-striata","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-04T22:33:19.125Z","creation":"2025-02-19T03:24:04.405Z"},"accession":"S-EPMC7334452","cross_references":{"pubmed":["32541059"],"doi":["10.1073/pnas.2002509117"]}}