{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(7)"],"submitter":["Papakyrikos AM"],"funding":["National Center for Research Resources","Stanford University","U.S. Department of Defense","National Science Foundation"],"pubmed_abstract":["The fly trachea is the equivalent of the mammalian lung and is a useful model for human respiratory diseases. However, little is known about the molecular mechanisms underlying tracheal air filling during larval development. In this study, we discover that PTPMT1 has a function in tracheal air filling. PTPMT1 is a widely conserved, ubiquitously expressed mitochondrial phosphatase. To reveal PTPMT1's functions in genetically tractable invertebrates and whether those functions are tissue specific, we generate a Drosophila model of PTPMT1 depletion. We find that fly PTPMT1 mutants show impairments in tracheal air filling and subsequent activation of innate immune responses. On a cellular level, these defects are preceded by aggregation of mitochondria within the tracheal epithelial cells. Our"],"journal":["iScience"],"pagination":["101285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7334580"],"repository":["biostudies-literature"],"pubmed_title":["Drosophila PTPMT1 Has a Function in Tracheal Air Filling."],"pmcid":["PMC7334580"],"pubmed_authors":["Kim MJ","Wang X","Papakyrikos AM"],"additional_accession":[]},"is_claimable":false,"name":"Drosophila PTPMT1 Has a Function in Tracheal Air Filling.","description":"The fly trachea is the equivalent of the mammalian lung and is a useful model for human respiratory diseases. However, little is known about the molecular mechanisms underlying tracheal air filling during larval development. In this study, we discover that PTPMT1 has a function in tracheal air filling. PTPMT1 is a widely conserved, ubiquitously expressed mitochondrial phosphatase. To reveal PTPMT1's functions in genetically tractable invertebrates and whether those functions are tissue specific, we generate a Drosophila model of PTPMT1 depletion. We find that fly PTPMT1 mutants show impairments in tracheal air filling and subsequent activation of innate immune responses. On a cellular level, these defects are preceded by aggregation of mitochondria within the tracheal epithelial cells. Our","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-07T16:31:27.873Z","creation":"2020-07-11T07:05:33Z"},"accession":"S-EPMC7334580","cross_references":{"pubmed":["32629421"],"doi":["10.1016/j.isci.2020.101285"]}}