{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nerozzi C"],"funding":["Ministerio de Ciencia, Innovación y Universidades","Agència de Gestió d&apos;Ajuts Universitaris i de Recerca","Universitat de Girona"],"pagination":["11026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7335210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["The wide use of glyphosate-based herbicides (GBHs) has become a matter of concern due to its potential harmful effects on human health, including men fertility. This study sought to investigate, using the pig as a model, the impact of pure glyphosate and its most known commercial formulation, Roundup, on sperm function and survival. With this purpose, fresh commercial semen doses were incubated with different concentrations (0-360 µg/mL) of glyphosate (GLY; exp. 1) or Roundup, at the equivalent GLY concentration (exp. 2), at 38 °C for 3 h. Glyphosate at 360 µg/mL significantly (P < 0.05) decreased sperm motility, viability, mitochondrial activity and acrosome integrity but had no detrimental effect at lower doses. On the other hand, Roundup did significantly (P < 0.05) reduce sperm motilit"],"journal":["Scientific reports"],"pubmed_title":["Effects of Roundup and its main component, glyphosate, upon mammalian sperm function and survival."],"pmcid":["PMC7335210"],"funding_grant_id":["2017-SGR-1229","RYC-2014-15581","IFUdG2018"],"pubmed_authors":["Recuero S","Nerozzi C","Bucci D","Yeste M","Galeati G","Spinaci M"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Roundup and its main component, glyphosate, upon mammalian sperm function and survival.","description":"The wide use of glyphosate-based herbicides (GBHs) has become a matter of concern due to its potential harmful effects on human health, including men fertility. This study sought to investigate, using the pig as a model, the impact of pure glyphosate and its most known commercial formulation, Roundup, on sperm function and survival. With this purpose, fresh commercial semen doses were incubated with different concentrations (0-360 µg/mL) of glyphosate (GLY; exp. 1) or Roundup, at the equivalent GLY concentration (exp. 2), at 38 °C for 3 h. Glyphosate at 360 µg/mL significantly (P < 0.05) decreased sperm motility, viability, mitochondrial activity and acrosome integrity but had no detrimental effect at lower doses. On the other hand, Roundup did significantly (P < 0.05) reduce sperm motilit","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T14:25:14.283Z","creation":"2020-07-11T07:05:53Z"},"accession":"S-EPMC7335210","cross_references":{"pubmed":["32620848"],"doi":["10.1038/s41598-020-67538-w"]}}