biostudies-literatureIto ASuntory FoundationJapan Society for the Promotion of Science3045-3058https://www.ebi.ac.uk/biostudies/studies/S-EPMC7336154biostudies-literatureUnknown41(11)Previous neuroimaging studies demonstrated that ventromedial prefrontal cortex (vmPFC) activity reflects how much an individual positively views each person (impression). Here, we investigated whether the degree to which individuals think others positively view them (reflected impression) is similarly tracked by activity in the vmPFC by using fMRI and speed-dating events. We also examined whether activity of the vmPFC in response to the faces of others would predict the impression formed through direct interactions with them. The task consisted of three sessions: pre-speed-dating fMRI, speed-dating events, and post-speed-dating fMRI (not reported here). During the pre-speed-dating fMRI, each participant passively viewed the faces of others whom they would meet in the subsequent speed-datinHuman brain mappingThe role of the ventromedial prefrontal cortex in automatic formation of impression and reflected impression.PMC7336154Grant for Groundbreaking Young ResearchersJSPS Postdoctoral Fellowship for Research Abroad19K16889Murakami YHasegawa ASakai SIzuma KTakeda KIto AYoshida KSawamura DfalseThe role of the ventromedial prefrontal cortex in automatic formation of impression and reflected impression.Previous neuroimaging studies demonstrated that ventromedial prefrontal cortex (vmPFC) activity reflects how much an individual positively views each person (impression). Here, we investigated whether the degree to which individuals think others positively view them (reflected impression) is similarly tracked by activity in the vmPFC by using fMRI and speed-dating events. We also examined whether activity of the vmPFC in response to the faces of others would predict the impression formed through direct interactions with them. The task consisted of three sessions: pre-speed-dating fMRI, speed-dating events, and post-speed-dating fMRI (not reported here). During the pre-speed-dating fMRI, each participant passively viewed the faces of others whom they would meet in the subsequent speed-datin2020-01-01T00:00:00Z2020 Aug2025-04-19T18:00:13.755Z2025-04-19T18:00:13.755ZS-EPMC73361543230154610.1002/hbm.24996