biostudies-literatureMak ACYNational Institute of Environmental Health SciencesTobacco-Related Disease Research ProgramEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNIEHS NIH HHSNIAID NIH HHSAmerican Asthma FoundationNHLBI NIH HHSGordon and Betty Moore FoundationNational Human Genome Research InstituteNational Eye InstituteNHLBINIDDK NIH HHSAlfred P. Sloan Foundation869-886https://www.ebi.ac.uk/biostudies/studies/S-EPMC7337089biostudies-literatureUnknown215(3)Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV₁), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine project, we identified a novel genetic association with FEV₁ on chromosome 12 in 867 African American children with asthma (<i>P</i> = 1.26 × 10^-8, β = 0.302). Conditional analysis within 1 Mb of the tag signal (rs73429450) yielded one major and two other weaker independent signals within this peak. We explored statistical and functional evidence for all variants in linkage disequilibrium with the three independent signals and yielded nine varGeneticsLung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand <i>KITLG/SCF</i> and Gene-By-Air-Pollution Interaction.PMC7337089R01 HL-118267R01 HL-141485R01 HL133433P30 ES0135083R01 HL-120393-02S1; contract HHSN268201800001IR01 AI079139R01 HL141845GBMF3834R01 HL-141992HHSN268201600032IR01 DK113003X01 HL-1345891R01 HD-085993-01R01 HL-135156-S1K01 HL-140218R01 ES-015794K01 HL14021824RT-0025R01 HL-133433R01 HL1419922013-10-27R01 HL1182673R01 HL-117626-02S1; contract HHSN268201800002I3R01 HL-117004-02S3P30 ES006694Huntsman SMartinez FDBurchard EGLee EYKeys KLZiv EKumar RHimes BEJoo JSalazar SChen ZWhite MJSaef BGermer SGui HSleiman PMSajuthi SEng CZody MCKang HMAbecasis GGilliland FDLurmann FReeves CNickerson DAXiao SJain DOh SSSeibold MAWilliams LKHu DWinterkorn LHakonarson HMak ACYWu ACfalseLung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand <i>KITLG/SCF</i> and Gene-By-Air-Pollution Interaction.Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV₁), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine project, we identified a novel genetic association with FEV₁ on chromosome 12 in 867 African American children with asthma (<i>P</i> = 1.26 × 10^-8, β = 0.302). Conditional analysis within 1 Mb of the tag signal (rs73429450) yielded one major and two other weaker independent signals within this peak. We explored statistical and functional evidence for all variants in linkage disequilibrium with the three independent signals and yielded nine var2020-01-01T00:00:00Z2020 Jul2025-04-18T18:10:14.852Z2021-02-20T04:55:45ZS-EPMC73370893232756410.1534/genetics.120.303231