biostudies-literatureUnknown62(7)Vihlborg P<h4>Objective</h4>To investigate whether low molecular organic biomarkers could be identified in blood samples from vibration exposed workers using a metabolomics.<h4>Methods</h4>The study population consisted of 38 metalworkers. All participants underwent a standardized medical examination. Blood samples were collected before and after work shift and analyzed with gas chromatography time-of-flight mass spectrometry. Multivariate modeling (orthogonal partial least-squares analysis with discriminant analysis [OPLS-DA]) were used to verify differences in metabolic profiles.<h4>Results</h4>Twenty-two study participants reported vascular symptoms judged as vibration-related. The metabolic profile from participants with vibration-induced white fingers (VWF) was distinctly separated from particiJournal of occupational and environmental medicine460-465https://www.ebi.ac.uk/biostudies/studies/S-EPMC7337105biostudies-literatureSerum Metabolites in Hand-Arm Vibration Exposed Workers.PMC7337105Hadrevi JEriksson KHagenbjork AVihlborg PBryngelsson ILGraff PfalseSerum Metabolites in Hand-Arm Vibration Exposed Workers.<h4>Objective</h4>To investigate whether low molecular organic biomarkers could be identified in blood samples from vibration exposed workers using a metabolomics.<h4>Methods</h4>The study population consisted of 38 metalworkers. All participants underwent a standardized medical examination. Blood samples were collected before and after work shift and analyzed with gas chromatography time-of-flight mass spectrometry. Multivariate modeling (orthogonal partial least-squares analysis with discriminant analysis [OPLS-DA]) were used to verify differences in metabolic profiles.<h4>Results</h4>Twenty-two study participants reported vascular symptoms judged as vibration-related. The metabolic profile from participants with vibration-induced white fingers (VWF) was distinctly separated from partici2020-01-01T00:00:00Z2020 Jul2025-04-19T18:02:22.097Z2025-04-19T18:02:22.097ZS-EPMC73371053273002010.1097/JOM.0000000000001864