biostudies-literatureYang DHui Hoy and Chow Sin Lan Charity Fund LimitedRespiratory Viral Research Foundation LimitedChan Yin Chuen Memorial Charitable FoundationShaw Foundation of Hong KongPerfect Shape Medical LimitedKai Chong TongMay Tam Mak Mei YinMichael Seak-Kan TongHigh Level-Hospital ProgramJessie and George Ho Charitable FoundationRichard Yu and Carol YuConsultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Diseases and Research Capability on Antimicrobial ResistanceMarina Man-Wai LeeNational Institute for Health Research (NIHR)Sanming Project of Medicine in ShenzhenResearch Grants CouncilHui MingHong Kong Hainan Commercial Association South China Microbiology Research FundHealth Commission of Guangdong Province734-745https://www.ebi.ac.uk/biostudies/studies/S-EPMC7337793biostudies-literatureUnknown222(5)Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. Dendritic cells and macrophages are sentinel cells for innate and adaptive immunity that affect the pathogenesis of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). The interplay between SARS-CoV-2 and these cell types remains unknown. We investigated infection and host responses of monocyte-derived dendritic cells (moDCs) and macrophages (MDMs) infected by SARS-CoV-2. MoDCs and MDMs were permissive to SARS-CoV-2 infection and protein expression but did not support productive virus replication. Importantly, SARS-CoV-2 launched an attenuated interferon response in both celThe Journal of infectious diseasesAttenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.PMC7337793T11/707/15SZSM201911014Cai JPYuan SYuen TTZhang AJChan JFShuai HYang DHou YHu BZhang XHuang XChu HYuen KYLee ACWang YChai YZhou JfalseAttenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. Dendritic cells and macrophages are sentinel cells for innate and adaptive immunity that affect the pathogenesis of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). The interplay between SARS-CoV-2 and these cell types remains unknown. We investigated infection and host responses of monocyte-derived dendritic cells (moDCs) and macrophages (MDMs) infected by SARS-CoV-2. MoDCs and MDMs were permissive to SARS-CoV-2 infection and protein expression but did not support productive virus replication. Importantly, SARS-CoV-2 launched an attenuated interferon response in both cel2020-01-01T00:00:00Z2020 Aug2025-04-04T15:03:19.891Z2020-09-05T07:11:37ZS-EPMC73377933256318710.1093/infdis/jiaa356