biostudies-literatureUnknown86(1)de Jong LAW<h4>Purpose</h4>In this exploratory study, the effect of postprocedural flushing with crystalloids after oxaliplatin-based hyperthermic intraperitoneal chemotherapy (HIPEC) on platinum concentrations in peritoneal tissue, blood, and drain fluid was studied. Interpatient variability in oxaliplatin pharmacokinetics and the relation between platinum concentration in peritoneal fluid and platinum exposure in tissue and blood was explored.<h4>Methods</h4>Ten patients with peritoneal carcinomatosis of colorectal origin were treated with HIPEC including postprocedural flushing, followed by ten patients without flushing afterwards. Tissue, peritoneal fluid, blood, and drain fluid samples were collected for measurement of total and ultrafiltered platinum concentrations.<h4>Results</h4>Peritoneal tiCancer chemotherapy and pharmacology141-150https://www.ebi.ac.uk/biostudies/studies/S-EPMC7338818biostudies-literatureWide variation in tissue, systemic, and drain fluid exposure after oxaliplatin-based HIPEC: results of the GUTOX study.PMC7338818Lambert MElekonawo FMKvan Erp NPVerheul HMWde Jong LAWde Gooyer JMde Reuver PRBremers AJAde Wilt JHWTer Heine RBurger DMChatelut EfalseWide variation in tissue, systemic, and drain fluid exposure after oxaliplatin-based HIPEC: results of the GUTOX study.<h4>Purpose</h4>In this exploratory study, the effect of postprocedural flushing with crystalloids after oxaliplatin-based hyperthermic intraperitoneal chemotherapy (HIPEC) on platinum concentrations in peritoneal tissue, blood, and drain fluid was studied. Interpatient variability in oxaliplatin pharmacokinetics and the relation between platinum concentration in peritoneal fluid and platinum exposure in tissue and blood was explored.<h4>Methods</h4>Ten patients with peritoneal carcinomatosis of colorectal origin were treated with HIPEC including postprocedural flushing, followed by ten patients without flushing afterwards. Tissue, peritoneal fluid, blood, and drain fluid samples were collected for measurement of total and ultrafiltered platinum concentrations.<h4>Results</h4>Peritoneal ti2020-01-01T00:00:00Z2020 Jul2025-04-04T03:24:41.05Z2021-02-20T07:30:42ZS-EPMC73388183259420010.1007/s00280-020-04107-y