biostudies-literatureUnknown86(1)Nagard MCancer Research UKNational Institute for Health Research (NIHR)AstraZeneca<h4>Purpose</h4>To support future dosing recommendations, the effect of food on the pharmacokinetics of adavosertib, a first-in-class, small-molecule reversible inhibitor of WEE1 kinase, was assessed in patients with advanced solid tumors.<h4>Methods</h4>In this Phase I, open-label, randomized, two-period, two-sequence crossover study, the pharmacokinetics of a single 300 mg adavosertib dose were investigated in fed versus fasted states.<h4>Results</h4>Compared with the fasted state, a high-fat, high-calorie meal (fed state) decreased adavosertib maximum plasma concentration (C_max) by 16% and systemic exposure (area under the plasma concentration-time curve [AUC]) by 6%; AUC_0-t decreased by 7% and time to maximum plasma concentration was delayed by 1.97 h (P = 0.0009)Cancer chemotherapy and pharmacology97-108https://www.ebi.ac.uk/biostudies/studies/S-EPMC7338825biostudies-literatureEffect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.PMC7338825Ah-See MLSo KVermunt MCampone MOttesen LRoxburgh PNagard MRavaud ALabots MValkenburg-van Iersel LLi YMugundu GThistlethwaite FfalseEffect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.<h4>Purpose</h4>To support future dosing recommendations, the effect of food on the pharmacokinetics of adavosertib, a first-in-class, small-molecule reversible inhibitor of WEE1 kinase, was assessed in patients with advanced solid tumors.<h4>Methods</h4>In this Phase I, open-label, randomized, two-period, two-sequence crossover study, the pharmacokinetics of a single 300 mg adavosertib dose were investigated in fed versus fasted states.<h4>Results</h4>Compared with the fasted state, a high-fat, high-calorie meal (fed state) decreased adavosertib maximum plasma concentration (C_max) by 16% and systemic exposure (area under the plasma concentration-time curve [AUC]) by 6%; AUC_0-t decreased by 7% and time to maximum plasma concentration was delayed by 1.97 h (P = 0.0009)2020-01-01T00:00:00Z2020 Jul2026-07-15T23:35:00.916Z2025-04-06T12:38:14.141ZS-EPMC73388253255660210.1007/s00280-020-04101-4