{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuntic M"],"funding":["Boehringer Ingelheim Foundation","NHLBI NIH HHS","Foundation Heart of Mainz","University Mainz"],"pagination":["2472-2483"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7340357"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(26)"],"pubmed_abstract":["<h4>Aims</h4>Electronic (e)-cigarettes have been marketed as a 'healthy' alternative to traditional combustible cigarettes and as an effective method of smoking cessation. There are, however, a paucity of data to support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction and oxidative stress in the vasculature and the lungs. The mechanisms underlying these side effects remain unclear. Here, we investigated the effects of e-cigarette vapour on vascular function in smokers and experimental animals to determine the underlying mechanisms.<h4>Methods and results</h4>Acute e-cigarette smoking produced a marked impairment of endothelial function in chronic smokers determined by flow-mediated dilation. In mice, e-cigarette vapour without nicotine had more detrimental eff"],"journal":["European heart journal"],"pubmed_title":["Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2)."],"pmcid":["PMC7340357"],"funding_grant_id":["R01 HL151626"],"pubmed_authors":["Munzel T","Kroller-Schon S","Filippou K","Vujacic-Mirski K","Bayo Jimenez MT","Varveri F","Daiber A","Daub S","Gori T","Hahad O","Kuntic M","Schmidt FP","Stamm P","Steven S","Bruckl V","Kalinovic S","Keaney JF","Frenis K","Kvandova M","Huesmann R","Hoffmann T","Oelze M","Al Zuabi A"],"additional_accession":[]},"is_claimable":false,"name":"Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2).","description":"<h4>Aims</h4>Electronic (e)-cigarettes have been marketed as a 'healthy' alternative to traditional combustible cigarettes and as an effective method of smoking cessation. There are, however, a paucity of data to support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction and oxidative stress in the vasculature and the lungs. The mechanisms underlying these side effects remain unclear. Here, we investigated the effects of e-cigarette vapour on vascular function in smokers and experimental animals to determine the underlying mechanisms.<h4>Methods and results</h4>Acute e-cigarette smoking produced a marked impairment of endothelial function in chronic smokers determined by flow-mediated dilation. In mice, e-cigarette vapour without nicotine had more detrimental eff","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-07T15:11:13.125Z","creation":"2022-07-19T16:30:45.112Z"},"accession":"S-EPMC7340357","cross_references":{"pubmed":["31715629"],"doi":["10.1093/eurheartj/ehz772"]}}