biostudies-literatureKuntic MBoehringer Ingelheim FoundationNHLBI NIH HHSFoundation Heart of MainzUniversity Mainz2472-2483https://www.ebi.ac.uk/biostudies/studies/S-EPMC7340357biostudies-literatureUnknown41(26)<h4>Aims</h4>Electronic (e)-cigarettes have been marketed as a 'healthy' alternative to traditional combustible cigarettes and as an effective method of smoking cessation. There are, however, a paucity of data to support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction and oxidative stress in the vasculature and the lungs. The mechanisms underlying these side effects remain unclear. Here, we investigated the effects of e-cigarette vapour on vascular function in smokers and experimental animals to determine the underlying mechanisms.<h4>Methods and results</h4>Acute e-cigarette smoking produced a marked impairment of endothelial function in chronic smokers determined by flow-mediated dilation. In mice, e-cigarette vapour without nicotine had more detrimental effEuropean heart journalShort-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2).PMC7340357R01 HL151626Munzel TKroller-Schon SFilippou KVujacic-Mirski KBayo Jimenez MTVarveri FDaiber ADaub SGori THahad OKuntic MSchmidt FPStamm PSteven SBruckl VKalinovic SKeaney JFFrenis KKvandova MHuesmann RHoffmann TOelze MAl Zuabi AfalseShort-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2).<h4>Aims</h4>Electronic (e)-cigarettes have been marketed as a 'healthy' alternative to traditional combustible cigarettes and as an effective method of smoking cessation. There are, however, a paucity of data to support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction and oxidative stress in the vasculature and the lungs. The mechanisms underlying these side effects remain unclear. Here, we investigated the effects of e-cigarette vapour on vascular function in smokers and experimental animals to determine the underlying mechanisms.<h4>Methods and results</h4>Acute e-cigarette smoking produced a marked impairment of endothelial function in chronic smokers determined by flow-mediated dilation. In mice, e-cigarette vapour without nicotine had more detrimental eff2020-01-01T00:00:00Z2020 Jul2026-05-07T15:11:13.125Z2022-07-19T16:30:45.112ZS-EPMC73403573171562910.1093/eurheartj/ehz772