biostudies-literatureBeards SEconomic and Social Research CouncilMRFBritish Academy Mid-Career FellowshipFramework ProgramHeisenberg professorship from the German Research FoundationERC Consolidator AwardSouth London and Maudsley NHS Foundation TrustMedical Research FoundationUK Department of Health via the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental HealthEuropean Research CouncilEuropean UnionMedical Research CouncilNational Institute for Health Research (NIHR)King’s College LondonESRC Centre for Society and Mental Health at King’s College LondonWellcome Trust814-822https://www.ebi.ac.uk/biostudies/studies/S-EPMC7342097biostudies-literatureUnknown46(4)<h4>Objective</h4>Stressful life events have been implicated in the onset of psychotic disorders, but there are few robust studies. We sought to examine the nature and magnitude of associations between adult life events and difficulties and first-episode psychoses, particularly focusing on contextual characteristics, including threat, intrusiveness, and independence.<h4>Method</h4>This study forms part of the Childhood Adversity and Psychosis Study (CAPsy), an epidemiological case-control study in London, United Kingdom. Data on life events and difficulties (problems lasting 4 wk or more) during 1 year prior to onset (cases) or interview (controls) were assessed using the semi-structured Life Events and Difficulties Schedule (LEDS). Data were available on 253 individuals with a first episoSchizophrenia bulletinThreatening Life Events and Difficulties and Psychotic Disorder.PMC7342097WT087417NIHR201376MRF_C0439HEALTH-F2-2009–241909G108/603ES/S012567/1C0439MD\170005ES/S004424/1648837 REACHNF-SI-0616-10074648837389624707Reininghaus UMurray RHubbard KMondelli VGayer-Anderson CCraig TJDi Forti MFisher HLBeards SMorgan CPariante CDazzan PfalseThreatening Life Events and Difficulties and Psychotic Disorder.<h4>Objective</h4>Stressful life events have been implicated in the onset of psychotic disorders, but there are few robust studies. We sought to examine the nature and magnitude of associations between adult life events and difficulties and first-episode psychoses, particularly focusing on contextual characteristics, including threat, intrusiveness, and independence.<h4>Method</h4>This study forms part of the Childhood Adversity and Psychosis Study (CAPsy), an epidemiological case-control study in London, United Kingdom. Data on life events and difficulties (problems lasting 4 wk or more) during 1 year prior to onset (cases) or interview (controls) were assessed using the semi-structured Life Events and Difficulties Schedule (LEDS). Data were available on 253 individuals with a first episo2020-01-01T00:00:00Z2020 Jul2025-04-19T18:02:00.882Z2025-04-19T18:02:00.882ZS-EPMC73420973204794010.1093/schbul/sbaa005