{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Levitt JJ"],"funding":["NIBIB NIH HHS","NIMH NIH HHS","NCI NIH HHS","VA Merit Awards"],"pagination":["990-998"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7342176"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(4)"],"pubmed_abstract":["We investigated brain wiring in chronic schizophrenia and healthy controls in frontostriatal circuits using diffusion magnetic resonance imaging tractography in a novel way. We extracted diffusion streamlines in 27 chronic schizophrenia and 26 healthy controls connecting 4 frontal subregions to the striatum. We labeled the projection zone striatal surface voxels into 2 subtypes: dominant-input from a single cortical subregion, and, functionally integrative, with mixed-input from diverse cortical subregions. We showed: 1) a group difference for total striatal surface voxel number (P = .045) driven by fewer mixed-input voxels in the left (P  = .007), but not right, hemisphere; 2) a group by hemisphere interaction for the ratio quotient between voxel subtypes (P  = .04) with a left (P  = .006"],"journal":["Schizophrenia bulletin"],"pubmed_title":["Miswiring of Frontostriatal Projections in Schizophrenia."],"pmcid":["PMC7342176"],"funding_grant_id":["K01 MH115247","CX000176","P41 EB015902","R01 MH074794","RO3 MH110745","P41 EB015898","R01 MH119222","P41EB015902","CX000157","R01MH074794","K01 MH115247-01A1","R01 MH102377","P41EB015898","R01 AG042512","U01 CA199459","U01CA199459"],"pubmed_authors":["Zhang F","Shenton ME","Nestor PG","Lyall AE","Kubicki M","O Donnell LJ","McCarley RW","Rathi Y","Riklin-Raviv T","Levitt JJ"],"additional_accession":[]},"is_claimable":false,"name":"Miswiring of Frontostriatal Projections in Schizophrenia.","description":"We investigated brain wiring in chronic schizophrenia and healthy controls in frontostriatal circuits using diffusion magnetic resonance imaging tractography in a novel way. We extracted diffusion streamlines in 27 chronic schizophrenia and 26 healthy controls connecting 4 frontal subregions to the striatum. We labeled the projection zone striatal surface voxels into 2 subtypes: dominant-input from a single cortical subregion, and, functionally integrative, with mixed-input from diverse cortical subregions. We showed: 1) a group difference for total striatal surface voxel number (P = .045) driven by fewer mixed-input voxels in the left (P  = .007), but not right, hemisphere; 2) a group by hemisphere interaction for the ratio quotient between voxel subtypes (P  = .04) with a left (P  = .006","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T08:38:55.976Z","creation":"2022-02-10T18:08:57.134Z"},"accession":"S-EPMC7342176","cross_references":{"pubmed":["31990358"],"doi":["10.1093/schbul/sbz129"]}}