biostudies-literatureLevitt JJNIBIB NIH HHSNIMH NIH HHSNCI NIH HHSVA Merit Awards990-998https://www.ebi.ac.uk/biostudies/studies/S-EPMC7342176biostudies-literatureUnknown46(4)We investigated brain wiring in chronic schizophrenia and healthy controls in frontostriatal circuits using diffusion magnetic resonance imaging tractography in a novel way. We extracted diffusion streamlines in 27 chronic schizophrenia and 26 healthy controls connecting 4 frontal subregions to the striatum. We labeled the projection zone striatal surface voxels into 2 subtypes: dominant-input from a single cortical subregion, and, functionally integrative, with mixed-input from diverse cortical subregions. We showed: 1) a group difference for total striatal surface voxel number (P = .045) driven by fewer mixed-input voxels in the left (P  = .007), but not right, hemisphere; 2) a group by hemisphere interaction for the ratio quotient between voxel subtypes (P  = .04) with a left (P  = .006Schizophrenia bulletinMiswiring of Frontostriatal Projections in Schizophrenia.PMC7342176K01 MH115247CX000176P41 EB015902R01 MH074794RO3 MH110745P41 EB015898R01 MH119222P41EB015902CX000157R01MH074794K01 MH115247-01A1R01 MH102377P41EB015898R01 AG042512U01 CA199459U01CA199459Zhang FShenton MENestor PGLyall AEKubicki MO Donnell LJMcCarley RWRathi YRiklin-Raviv TLevitt JJfalseMiswiring of Frontostriatal Projections in Schizophrenia.We investigated brain wiring in chronic schizophrenia and healthy controls in frontostriatal circuits using diffusion magnetic resonance imaging tractography in a novel way. We extracted diffusion streamlines in 27 chronic schizophrenia and 26 healthy controls connecting 4 frontal subregions to the striatum. We labeled the projection zone striatal surface voxels into 2 subtypes: dominant-input from a single cortical subregion, and, functionally integrative, with mixed-input from diverse cortical subregions. We showed: 1) a group difference for total striatal surface voxel number (P = .045) driven by fewer mixed-input voxels in the left (P  = .007), but not right, hemisphere; 2) a group by hemisphere interaction for the ratio quotient between voxel subtypes (P  = .04) with a left (P  = .0062020-01-01T00:00:00Z2020 Jul2025-04-04T08:38:55.976Z2022-02-10T18:08:57.134ZS-EPMC73421763199035810.1093/schbul/sbz129