{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(12)"],"submitter":["Bock JO"],"pubmed_abstract":["Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced <i>in vitro</i> by SARS-CoV-2. Here, we use the publicly available proteomics data from this study to re-analyze the <i>in vitro</i> cellular consequences of SARS-CoV-2 infection by impact pathways analysis and network analysis. Notably, proteins linked to the inflammatory response, but also pro"],"journal":["Aging"],"pagination":["11277-11286"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7343490"],"repository":["biostudies-literature"],"pubmed_title":["Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response."],"pmcid":["PMC7343490"],"pubmed_authors":["Ortea I","Bock JO"],"additional_accession":[]},"is_claimable":false,"name":"Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response.","description":"Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced <i>in vitro</i> by SARS-CoV-2. Here, we use the publicly available proteomics data from this study to re-analyze the <i>in vitro</i> cellular consequences of SARS-CoV-2 infection by impact pathways analysis and network analysis. Notably, proteins linked to the inflammatory response, but also pro","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-22T19:30:45.706Z","creation":"2020-10-01T07:04:57Z"},"accession":"S-EPMC7343490","cross_references":{"pubmed":["32575076"],"doi":["10.18632/aging.103524"]}}