biostudies-literatureVujkovic MBLRD VANIDDK NIH HHSNIEHS NIH HHSNIAID NIH HHSMedical Research CouncilNHLBI NIH HHSNHGRI NIH HHSCSRD VA680-691https://www.ebi.ac.uk/biostudies/studies/S-EPMC7343592biostudies-literatureUnknown52(7)We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score (PRS) was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD) and neuropathy. We investigated the genetic etiolNature geneticsDiscovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.PMC7343592R03 AI133172R01 DK087635T32 HL007734IK2 CX001780I01 CX001737P30 DK111024R01 HG010067HDR-9004U34 DK091958R56 DK101478I01 CX001025I01 BX004821U01 DK098246I01 BX003362R01 DK101478UM1 DK078616R21 DK099716P30 DK123704UC4 DK112217P30 ES006694Huang GDMiller DRAguayo SMMelander OWolf SEGreco JAVujkovic MWhitbourne SBLynch JABaras ABlumenfeld ALDamrauer SMHPAP ConsortiumChang KMIruvanti PRArgyres DPGutierrez SConnor TWidom LKinlay SDellitalia LJReaven PDHauser ERGodschalk MDuVall SLMoser JHumphries DEBrewer JVMallick NHEdwards TLSharma SCXu JLichy JHWhooley MABeckham JCMorgan TRSonel EJalal AWells JMMathew ROGibson GHuq MVoight BFIvins DJHung AMMoorman JPHuffman JEMeigs JBEom GLiangpunsakul SHameed SFernando RSRauchman MIRatcliffe NRNaji AStapley TLotta LATandon NJones MBNguyen XTZhou JZhao HMaxwell EKRasheed AManoochehri KRobey RBStriker RTGupta SForsythe CBalasubramanian SKlarin DFuller EDSriram PBai XYadav AWallbom ASRegeneron Genetics CenterJhala DNMurdoch MKeaton JMLee KMAtkinson MACohen DMZhu XBarnard LFlorez HJMeyer LJStaples JCHuang JQureshi IHVA Million Veteran ProgramAbecasis GRToledo KPowers ACCoppola GStephens BHammer KDLee JSBreeling JLKaestner KHHurley RAEconomides ANMattocks KMGaddy MAKaminsky LSMastorides SMAfzal MNVillareal GSheng XTsao PSLattari MAslan MHabegger LShuldiner ARWhittle JCBrophy MTPradhan MDo NVJacono FJPadilla MSUlloa RHGao LAssimes TLSherman SEHamner MBRader DJRoss GWSusztak KWilson PWPhillips LSBoyko EJOkusaga OOOverton JDRamoni RBMuralidhar SPyarajan SHawes AAhuja SKBallas ZKCantor MNGappy SSConcato JServatius RJRomero JPCSun YVCho KSchleicher TDDanesh JTcheandjieu CHarley JBSelva LEMitnaul LJYeh SSSalerno WJKhalid SReid JGConstans JIKlein JBAbbas SMalik UO'Donnell CJBeechert CGu ZShayan SFayad JMHilliard ATLopez AEMcArdle RLorenz KJudy RLBhushan SSaleheen DGaziano JMOursler KKMeyer PNfalseDiscovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score (PRS) was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD) and neuropathy. We investigated the genetic etiol2020-01-01T00:00:00Z2020 Jul2026-05-03T08:14:36.75Z2021-02-20T11:33:09ZS-EPMC73435923254192510.1038/s41588-020-0637-y