{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taylor A"],"funding":["Kidney Research UK","Medical Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["904-913"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7343735"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["Purpose
The question of whether mesenchymal stromal cells (MSCs) home to injured kidneys remains a contested issue. To try and understand the basis for contradictory findings reported in the literature, our purpose here was to investigate whether MSC homing capacity is influenced by administration route, the type of injury model used, and/or the presence of exogenous macrophages.Procedures
To assess the viability, whole-body biodistribution, and intra-renal biodistribution of MSCs, we used a multimodal imaging strategy comprising bioluminescence and magnetic resonance imaging. The effect of administration route (venous or arterial) on the ability of MSCs to home to injured renal tissue, and persist there, was assessed in a glomerular injury model (induced by the nephrotoxic"],"journal":["Molecular imaging and biology"],"pubmed_title":["Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models."],"pmcid":["PMC7343735"],"funding_grant_id":["MR/K026739/1","RP_038_20180306","TF_010_20171124","MR/L012707/1"],"pubmed_authors":["Harwood R","Murray P","Sharkey J","Rosseinsky MJ","Adams DJ","Barrow M","Scarfe L","Wilm B","Taylor A"],"additional_accession":[]},"is_claimable":false,"name":"Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models.","description":"Purpose
The question of whether mesenchymal stromal cells (MSCs) home to injured kidneys remains a contested issue. To try and understand the basis for contradictory findings reported in the literature, our purpose here was to investigate whether MSC homing capacity is influenced by administration route, the type of injury model used, and/or the presence of exogenous macrophages.Procedures
To assess the viability, whole-body biodistribution, and intra-renal biodistribution of MSCs, we used a multimodal imaging strategy comprising bioluminescence and magnetic resonance imaging. The effect of administration route (venous or arterial) on the ability of MSCs to home to injured renal tissue, and persist there, was assessed in a glomerular injury model (induced by the nephrotoxic","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-26T08:14:40.259Z","creation":"2025-04-06T12:36:31.643Z"},"accession":"S-EPMC7343735","cross_references":{"pubmed":["31823201"],"doi":["10.1007/s11307-019-01458-8"]}}