{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(7)"],"submitter":["Yang D"],"pubmed_abstract":["Cancer stem cell (CSC) is a challenge in the therapy of triple-negative breast cancer (TNBC). Intratumoral hypoxia is a common feature of solid tumor. Hypoxia may contribute to the maintenance of CSC, resulting in a poor efficacy of traditional treatment and recurrence of TNBC cases. However, the underlying molecular mechanism involved in hypoxia-induced CSC stemness maintenance remains unclear. Here, we report that hypoxia stimulated DNA double-strand breaks independent of ATM kinase activation (called oxidized ATM in this paper) play a crucial role in TNBC mammosphere formation and stemness maintenance by governing a specific energy metabolism reprogramming (EMR). Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rathe"],"journal":["Cell death & disease"],"pagination":["508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7343870"],"repository":["biostudies-literature"],"pubmed_title":["Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation."],"pmcid":["PMC7343870"],"pubmed_authors":["Yang L","Liu M","Jin T","Qin Y","Li Q","Wan X","Liu S","Yang D","Hou Y","Qiu Y","Zhu P","Zeng H","Peng M"],"additional_accession":[]},"is_claimable":false,"name":"Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation.","description":"Cancer stem cell (CSC) is a challenge in the therapy of triple-negative breast cancer (TNBC). Intratumoral hypoxia is a common feature of solid tumor. Hypoxia may contribute to the maintenance of CSC, resulting in a poor efficacy of traditional treatment and recurrence of TNBC cases. However, the underlying molecular mechanism involved in hypoxia-induced CSC stemness maintenance remains unclear. Here, we report that hypoxia stimulated DNA double-strand breaks independent of ATM kinase activation (called oxidized ATM in this paper) play a crucial role in TNBC mammosphere formation and stemness maintenance by governing a specific energy metabolism reprogramming (EMR). Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rathe","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-06-04T07:56:52.365Z","creation":"2025-04-19T18:00:46.934Z"},"accession":"S-EPMC7343870","cross_references":{"pubmed":["32641713"],"doi":["10.1038/s41419-020-2714-7"]}}