{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma S"],"funding":["Ministry of Education","Ministry of Oceans and Fisheries"],"pagination":["E265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7344672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Vibrio harveyi is one of the pathogens that threaten the shrimp farming industry. However, metabolic changes induced by V. harveyi infection in shrimp remain unknown. In this study, we first conducted high resolution-magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR)-based metabolomics studies on gill, hepatopancreas, and haemolymph of V. harveyi-infected white leg shrimp, Litopenaeus vannamei. Using multivariate statistical analysis, we observed a clear separation between the early (3 and 9 h post-injection (hpi)) and late phases (24, 72 and 144 hpi) of the infection in all tissues. Moreover, metabolic changes in response to V. harveyi infection were faster in the haemolymph in the early phase and significantly changed in the late phase of the infection in the gills. Extensive"],"journal":["Metabolites"],"pubmed_title":["Vibrio harveyi Infection Significantly Alters Amino Acid and Carbohydrate Metabolism in Whiteleg Shrimp, Litopenaeus vannamei."],"pmcid":["PMC7344672"],"funding_grant_id":["Omics based on fishery disease control technology development and industrialization (20150242)","National Research Foundation of Korea (NRF-2017R1A2B4006648)"],"pubmed_authors":["Kim S","Lee S","Kim A","Ma S","Yoon D","Bae JS","Park CI","Lee W"],"additional_accession":[]},"is_claimable":false,"name":"Vibrio harveyi Infection Significantly Alters Amino Acid and Carbohydrate Metabolism in Whiteleg Shrimp, Litopenaeus vannamei.","description":"Vibrio harveyi is one of the pathogens that threaten the shrimp farming industry. However, metabolic changes induced by V. harveyi infection in shrimp remain unknown. In this study, we first conducted high resolution-magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR)-based metabolomics studies on gill, hepatopancreas, and haemolymph of V. harveyi-infected white leg shrimp, Litopenaeus vannamei. Using multivariate statistical analysis, we observed a clear separation between the early (3 and 9 h post-injection (hpi)) and late phases (24, 72 and 144 hpi) of the infection in all tissues. Moreover, metabolic changes in response to V. harveyi infection were faster in the haemolymph in the early phase and significantly changed in the late phase of the infection in the gills. Extensive","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-22T19:35:06.988Z","creation":"2025-04-06T02:46:41.897Z"},"accession":"S-EPMC7344672","cross_references":{"pubmed":["32630518"],"doi":["10.3390/metabo10060265"]}}