{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(4)"],"submitter":["Douglas KM"],"pubmed_abstract":["<h4>Background</h4>Cognitive impairment is considered a core feature of major depressive disorder (MDD) and research into psychological treatments aiming to address cognitive impairment are gaining momentum. Compared with the well-established research base of cognitive treatment trials in schizophrenia, including meta-analyses, mood disorder research is much more preliminary.<h4>Aims</h4>To focus on identifying the important factors to consider in developing larger-scale psychological treatment trials targeting cognitive impairment in mood disorders. Trial design recommendations have been published for cognitive treatment trials in bipolar disorder.<h4>Method</h4>An in-depth discussion of methodological considerations in the development of cognitive treatment trials for MDD.<h4>Results</h4>Methodological considerations include: screening for, and defining, cognitive impairment; mood state when cognitive intervention begins; medication monitoring during cognitive interventions; use of concomitant therapy; level of therapist involvement; duration and dose of treatment; choice of specific cognitive training exercises; home practice; improving adherence; appropriate comparison therapies in clinical trials; and choice of primary outcomes.<h4>Conclusions</h4>As well as guidance for clinical trial development, this review may be helpful for clinicians wanting to provide cognitive interventions for individuals with MDD."],"journal":["BJPsych open"],"pagination":["e67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7345587"],"repository":["biostudies-literature"],"pubmed_title":["Clinical and methodological considerations for psychological treatment of cognitive impairment in major depressive disorder."],"pmcid":["PMC7345587"],"pubmed_authors":["Douglas KM","Bowie CR","Milanovic M","Porter RJ"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and methodological considerations for psychological treatment of cognitive impairment in major depressive disorder.","description":"<h4>Background</h4>Cognitive impairment is considered a core feature of major depressive disorder (MDD) and research into psychological treatments aiming to address cognitive impairment are gaining momentum. Compared with the well-established research base of cognitive treatment trials in schizophrenia, including meta-analyses, mood disorder research is much more preliminary.<h4>Aims</h4>To focus on identifying the important factors to consider in developing larger-scale psychological treatment trials targeting cognitive impairment in mood disorders. Trial design recommendations have been published for cognitive treatment trials in bipolar disorder.<h4>Method</h4>An in-depth discussion of methodological considerations in the development of cognitive treatment trials for MDD.<h4>Results</h4>Methodological considerations include: screening for, and defining, cognitive impairment; mood state when cognitive intervention begins; medication monitoring during cognitive interventions; use of concomitant therapy; level of therapist involvement; duration and dose of treatment; choice of specific cognitive training exercises; home practice; improving adherence; appropriate comparison therapies in clinical trials; and choice of primary outcomes.<h4>Conclusions</h4>As well as guidance for clinical trial development, this review may be helpful for clinicians wanting to provide cognitive interventions for individuals with MDD.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-22T19:33:07.413Z","creation":"2025-04-06T02:46:31.75Z"},"accession":"S-EPMC7345587","cross_references":{"pubmed":["32594951"],"doi":["10.1192/bjo.2020.53"]}}