{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(6)"],"submitter":["Crespo G"],"pubmed_abstract":["An antifungal lipodepsipeptide was obtained from cultures of the fungus Foliophoma fallens CF-236885. Its structure, elucidated by HRMS and NMR spectroscopy, contained Gly, Thr, Asn, β-Ala, Orn, Ala, two Ser residues, and 3-hydroxy-4-methylhexadecanoic acid. The absolute configuration of its amino acid residues was determined using Marfey's analysis and J-based configuration analysis helped to establish the relative configuration of the 3-hydroxy-4-methylhexadecanoic acid moiety. A literature search retrieved a patent describing antibiotic TKR2999 (1), whose non-disclosed structure was confirmed to be identical to that found for our compound, according to its physicochemical properties and NMR spectra. Compound 1 displayed potent antifungal activity against Aspergillus fumigatus and a pane"],"journal":["Antibiotics (Basel, Switzerland)"],"pagination":["E278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7345921"],"repository":["biostudies-literature"],"pubmed_title":["Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens."],"pmcid":["PMC7345921"],"pubmed_authors":["Gonzalez-Menendez V","Sanchez P","Crespo G","Cautain B","de la Cruz M","Reyes F","Perez-Victoria I","Ortiz-Lopez FJ","Genilloud O","Vicente F"],"additional_accession":[]},"is_claimable":false,"name":"Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens.","description":"An antifungal lipodepsipeptide was obtained from cultures of the fungus Foliophoma fallens CF-236885. Its structure, elucidated by HRMS and NMR spectroscopy, contained Gly, Thr, Asn, β-Ala, Orn, Ala, two Ser residues, and 3-hydroxy-4-methylhexadecanoic acid. The absolute configuration of its amino acid residues was determined using Marfey's analysis and J-based configuration analysis helped to establish the relative configuration of the 3-hydroxy-4-methylhexadecanoic acid moiety. A literature search retrieved a patent describing antibiotic TKR2999 (1), whose non-disclosed structure was confirmed to be identical to that found for our compound, according to its physicochemical properties and NMR spectra. Compound 1 displayed potent antifungal activity against Aspergillus fumigatus and a pane","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-22T19:38:00.26Z","creation":"2025-04-06T02:48:09.34Z"},"accession":"S-EPMC7345921","cross_references":{"pubmed":["32466351"],"doi":["10.3390/antibiotics9060278"]}}