{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Li Y"],"pubmed_abstract":["Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials & methods: A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SARS-related coronaviruses) on synonymous sites by using sequence alignment. We re-analyzed the sequences of the two coronaviruses with the same methodology. Results: We found that 87% of the synonymous substitutions between the two coronaviruses could be potentially explained by the RNA modification system in hosts, with 65% contributed by deamination on cytidines (C-T mismatches) and 22% contributed by deamination on adenosines (A-G mismatches). Conclusion: Our results demonstrate that the divergence"],"journal":["Future virology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7346715"],"repository":["biostudies-literature"],"pubmed_title":["The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification"],"pmcid":["PMC7346715"],"pubmed_authors":["Yang X","Wang N","Li Y","Jiang W","Yin B","Wang H"],"additional_accession":[]},"is_claimable":false,"name":"The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification","description":"Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials & methods: A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SARS-related coronaviruses) on synonymous sites by using sequence alignment. We re-analyzed the sequences of the two coronaviruses with the same methodology. Results: We found that 87% of the synonymous substitutions between the two coronaviruses could be potentially explained by the RNA modification system in hosts, with 65% contributed by deamination on cytidines (C-T mismatches) and 22% contributed by deamination on adenosines (A-G mismatches). Conclusion: Our results demonstrate that the divergence","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-06-01T02:34:57.323Z","creation":"2021-02-19T22:03:16Z"},"accession":"S-EPMC7346715","cross_references":{}}