{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azevedo AW"],"funding":["Pew Biomedical Trust","Searle Foundation","NIDCD NIH HHS","National Institute on Deafness and Other Communication Disorders","NINDS NIH HHS","Alfred P. Sloan Foundation","National Institutes of Health","NIH HHS","McKnight Foundation"],"pagination":["e56754"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7347388"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control flexion of the fruit fly tibia. We find that leg motor neurons exhibit a coordinated gradient of anatomical, physiological, and functional properties. Large, fast motor neurons control high force, ballistic movements while small, slow motor neurons control low force, postural movements. Intermediate neurons fall between these two extremes. This hierarchical organization resembles the size principle, first proposed as a mechanism for establishing recruitment order among vertebrate motor neurons. Recordings in behaving flies confirmed that moto"],"journal":["eLife"],"pubmed_title":["A size principle for recruitment of <i>Drosophila</i> leg motor neurons."],"pmcid":["PMC7347388"],"funding_grant_id":["R01 NS070644","S10 OD016240","U19NS104655","Research Fellowship","F32 DC013928","U19 NS104655","R01 NS102333","P40 OD018537","Scholar Award"],"pubmed_authors":["Gurung P","Tuthill JC","Azevedo AW","Venkatasubramanian L","Mann RS","Dickinson ES"],"additional_accession":[]},"is_claimable":false,"name":"A size principle for recruitment of <i>Drosophila</i> leg motor neurons.","description":"To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control flexion of the fruit fly tibia. We find that leg motor neurons exhibit a coordinated gradient of anatomical, physiological, and functional properties. Large, fast motor neurons control high force, ballistic movements while small, slow motor neurons control low force, postural movements. Intermediate neurons fall between these two extremes. This hierarchical organization resembles the size principle, first proposed as a mechanism for establishing recruitment order among vertebrate motor neurons. Recordings in behaving flies confirmed that moto","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-07-16T07:12:33.104Z","creation":"2026-07-09T10:43:27.636Z"},"accession":"S-EPMC7347388","cross_references":{"pubmed":["32490810"],"doi":["10.7554/eLife.56754"]}}