biostudies-literatureUnknown8(8)Wizenty JHelicobacter pylori (H. pylori) are gram-negative bacteria that are able to colonize and persist in the stomach. Gastric cancer is tightly linked to chronic infection with this bacterium. Research over the last decades has illuminated the molecular interactions between H. pylori and host cells. It is now well established that H. pylori have multiple sophisticated means to adhere to epithelial cells and to manipulate their behavior. This interaction with the epithelium can lead to altered cell signaling, DNA damage and aberrant epithelial immunity. H. pylori are known to colonize the mucus layer of the stomach and surface epithelial cells. In addition, it has recently become clear that they can also penetrate the glands and directly interact with specialized epithelial cells deep in the glaAnnals of translational medicine568https://www.ebi.ac.uk/biostudies/studies/S-EPMC7347775biostudies-literatureResponses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.PMC7347775Tacke FSigal MWizenty JfalseResponses of gastric epithelial stem cells and their niche to Helicobacter pylori infection.Helicobacter pylori (H. pylori) are gram-negative bacteria that are able to colonize and persist in the stomach. Gastric cancer is tightly linked to chronic infection with this bacterium. Research over the last decades has illuminated the molecular interactions between H. pylori and host cells. It is now well established that H. pylori have multiple sophisticated means to adhere to epithelial cells and to manipulate their behavior. This interaction with the epithelium can lead to altered cell signaling, DNA damage and aberrant epithelial immunity. H. pylori are known to colonize the mucus layer of the stomach and surface epithelial cells. In addition, it has recently become clear that they can also penetrate the glands and directly interact with specialized epithelial cells deep in the gla2020-01-01T00:00:00Z2020 Apr2025-04-05T20:14:04.464Z2025-04-05T20:14:04.464ZS-EPMC73477753277536910.21037/atm.2020.02.178