{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pereiro P"],"funding":["Xunta de Galicia","Interreg"],"pagination":["E199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7349019"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(2)"],"pubmed_abstract":["The PTEN (phosphatase and TENsin homolog on chromosome 10) gene encodes a bifunctional phosphatase that acts as a tumor suppressor. However, PTEN has been implicated in different immune processes, including autophagy, inflammation, regulation of natural killer (NK) cell cytolytic activity and type I interferon responses. Unlike mammals, zebrafish possess two pten genes (ptena and ptenb). This study explores the involvement of both zebrafish pten genes in antiviral defense. Although ptena-/- and ptenb-/- larvae were more susceptible to Spring viremia of carp virus (SVCV), the viral replication rate was lower in the mutant larvae than in the wild-type larvae. We observed that both mutant lines showed alterations in the transcription of numerous genes, including those related to the type I in"],"journal":["Vaccines"],"pubmed_title":["Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity."],"pmcid":["PMC7349019"],"funding_grant_id":["IN607B 2019/01","OPE01833","IN606B-2018/010"],"pubmed_authors":["Figueras A","Pereiro P","Novoa B"],"additional_accession":[]},"is_claimable":false,"name":"Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity.","description":"The PTEN (phosphatase and TENsin homolog on chromosome 10) gene encodes a bifunctional phosphatase that acts as a tumor suppressor. However, PTEN has been implicated in different immune processes, including autophagy, inflammation, regulation of natural killer (NK) cell cytolytic activity and type I interferon responses. Unlike mammals, zebrafish possess two pten genes (ptena and ptenb). This study explores the involvement of both zebrafish pten genes in antiviral defense. Although ptena-/- and ptenb-/- larvae were more susceptible to Spring viremia of carp virus (SVCV), the viral replication rate was lower in the mutant larvae than in the wild-type larvae. We observed that both mutant lines showed alterations in the transcription of numerous genes, including those related to the type I in","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-26T08:14:18.795Z","creation":"2025-02-19T00:50:43.718Z"},"accession":"S-EPMC7349019","cross_references":{"pubmed":["32357549"],"doi":["10.3390/vaccines8020199"]}}