biostudies-literaturePereiro PXunta de GaliciaInterregE199https://www.ebi.ac.uk/biostudies/studies/S-EPMC7349019biostudies-literatureUnknown8(2)The PTEN (phosphatase and TENsin homolog on chromosome 10) gene encodes a bifunctional phosphatase that acts as a tumor suppressor. However, PTEN has been implicated in different immune processes, including autophagy, inflammation, regulation of natural killer (NK) cell cytolytic activity and type I interferon responses. Unlike mammals, zebrafish possess two pten genes (ptena and ptenb). This study explores the involvement of both zebrafish pten genes in antiviral defense. Although ptena-/- and ptenb-/- larvae were more susceptible to Spring viremia of carp virus (SVCV), the viral replication rate was lower in the mutant larvae than in the wild-type larvae. We observed that both mutant lines showed alterations in the transcription of numerous genes, including those related to the type I inVaccinesZebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity.PMC7349019IN607B 2019/01OPE01833IN606B-2018/010Figueras APereiro PNovoa BfalseZebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity.The PTEN (phosphatase and TENsin homolog on chromosome 10) gene encodes a bifunctional phosphatase that acts as a tumor suppressor. However, PTEN has been implicated in different immune processes, including autophagy, inflammation, regulation of natural killer (NK) cell cytolytic activity and type I interferon responses. Unlike mammals, zebrafish possess two pten genes (ptena and ptenb). This study explores the involvement of both zebrafish pten genes in antiviral defense. Although ptena-/- and ptenb-/- larvae were more susceptible to Spring viremia of carp virus (SVCV), the viral replication rate was lower in the mutant larvae than in the wild-type larvae. We observed that both mutant lines showed alterations in the transcription of numerous genes, including those related to the type I in2020-01-01T00:00:00Z2020 Apr2025-04-26T08:14:18.795Z2025-02-19T00:50:43.718ZS-EPMC73490193235754910.3390/vaccines8020199