biostudies-literatureUnknown11(6)Miller JWSymbiotic interactions exist within a parasitism to mutualism continuum that is influenced, among others, by genes and context. Dynamics of intracellular invasion, replication, and prevalence may underscore both host survivability and symbiont stability. More infectious symbionts might exert higher corresponding costs to hosts, which could ultimately disadvantage both partners. Here, we quantify infection patterns of diverse <i>Paraburkholderia</i> symbiont genotypes in their amoeba host <i>Dictyostelium discoideum</i> and probe the relationship between these patterns and host outcomes. We exposed <i>D. discoideum</i> to thirteen strains of <i>Paraburkholderia</i> each belonging to one of the three symbiont species found to naturally infect <i>D. discoideum</i>: <i>Paraburkholderia agricolGenesE674https://www.ebi.ac.uk/biostudies/studies/S-EPMC7349545biostudies-literature<i>Paraburkholderia</i> Symbionts Display Variable Infection Patterns That Are Not Predictive of Amoeba Host Outcomes.PMC7349545Tresslar ARMiller JWSchniepp EMDiSalvo SBocke CRfalse<i>Paraburkholderia</i> Symbionts Display Variable Infection Patterns That Are Not Predictive of Amoeba Host Outcomes.Symbiotic interactions exist within a parasitism to mutualism continuum that is influenced, among others, by genes and context. Dynamics of intracellular invasion, replication, and prevalence may underscore both host survivability and symbiont stability. More infectious symbionts might exert higher corresponding costs to hosts, which could ultimately disadvantage both partners. Here, we quantify infection patterns of diverse <i>Paraburkholderia</i> symbiont genotypes in their amoeba host <i>Dictyostelium discoideum</i> and probe the relationship between these patterns and host outcomes. We exposed <i>D. discoideum</i> to thirteen strains of <i>Paraburkholderia</i> each belonging to one of the three symbiont species found to naturally infect <i>D. discoideum</i>: <i>Paraburkholderia agricol2020-01-01T00:00:00Z2020 Jun2026-04-07T13:30:00.777Z2020-10-01T07:04:59ZS-EPMC73495453257574710.3390/genes11060674