{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Go RCP"],"funding":["National Institute of Neurological Disorders and Stroke","Office of Research and Development","NIA NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","NIMHD NIH HHS","U.S. Army Medical Research Acquisition Activity","NINDS NIH HHS","National Institutes of Health","National Institute on Aging","NIH HHS","Michael J. Fox Foundation for Parkinson&apos;s Research"],"pagination":["31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7350633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>Parkinson's disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person's risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases.<h4>Results</h4>We measured genome-wide DNA methylation using the Illumina Infinium HumanMethylation450K BeadChip array in matched peripheral blood and postmortem brain biospecimens in PD cases (n = 20) assessed for years of plantation work and presence of organochlorines in brain tissue. The comparison of 10+ to 0 years of plantation work exposure detected"],"journal":["BMC neuroscience"],"pubmed_title":["Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity."],"pmcid":["PMC7350633"],"funding_grant_id":["5 R21 MH114005","5 R01 NS041265","R01 AG017155","5 K01 HL125504","R01 NS041265","5 R01 AG017155","U54 MD007601","1 U01 AG19349","WX81XWH-13-1-0085","DAMD17-98-1-8621","Rapid Response Innovation Award","R21 MH114005","K01 HL140271","5 P20 GM103457"],"pubmed_authors":["Ross GW","Go RCP","Masaki KH","Maunakea AK","Tiirikainen MI","Corley MJ","Petrovitch H","He Q"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity.","description":"<h4>Background</h4>Parkinson's disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person's risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases.<h4>Results</h4>We measured genome-wide DNA methylation using the Illumina Infinium HumanMethylation450K BeadChip array in matched peripheral blood and postmortem brain biospecimens in PD cases (n = 20) assessed for years of plantation work and presence of organochlorines in brain tissue. The comparison of 10+ to 0 years of plantation work exposure detected","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-04-12T19:50:59.903Z","creation":"2020-11-19T16:52:59Z"},"accession":"S-EPMC7350633","cross_references":{"pubmed":["32650713"],"doi":["10.1186/s12868-020-00582-4"]}}