biostudies-literatureGo RCPNational Institute of Neurological Disorders and StrokeOffice of Research and DevelopmentNIA NIH HHSNHLBI NIH HHSNIMH NIH HHSNIMHD NIH HHSU.S. Army Medical Research Acquisition ActivityNINDS NIH HHSNational Institutes of HealthNational Institute on AgingNIH HHSMichael J. Fox Foundation for Parkinson&apos;s Research31https://www.ebi.ac.uk/biostudies/studies/S-EPMC7350633biostudies-literatureUnknown21(1)<h4>Background</h4>Parkinson's disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person's risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases.<h4>Results</h4>We measured genome-wide DNA methylation using the Illumina Infinium HumanMethylation450K BeadChip array in matched peripheral blood and postmortem brain biospecimens in PD cases (n = 20) assessed for years of plantation work and presence of organochlorines in brain tissue. The comparison of 10+ to 0 years of plantation work exposure detectedBMC neuroscienceGenome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity.PMC73506335 R21 MH1140055 R01 NS041265R01 AG0171555 K01 HL125504R01 NS0412655 R01 AG017155U54 MD0076011 U01 AG19349WX81XWH-13-1-0085DAMD17-98-1-8621Rapid Response Innovation AwardR21 MH114005K01 HL1402715 P20 GM103457Ross GWGo RCPMasaki KHMaunakea AKTiirikainen MICorley MJPetrovitch HHe QfalseGenome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity.<h4>Background</h4>Parkinson's disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person's risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases.<h4>Results</h4>We measured genome-wide DNA methylation using the Illumina Infinium HumanMethylation450K BeadChip array in matched peripheral blood and postmortem brain biospecimens in PD cases (n = 20) assessed for years of plantation work and presence of organochlorines in brain tissue. The comparison of 10+ to 0 years of plantation work exposure detected2020-01-01T00:00:00Z2020 Jul2026-04-12T19:50:59.903Z2020-11-19T16:52:59ZS-EPMC73506333265071310.1186/s12868-020-00582-4