biostudies-literatureYan LThe key project of food safety of the Science and Technology Ministry of ChinaNational Natural Science Foundation of Chinae9306https://www.ebi.ac.uk/biostudies/studies/S-EPMC7350924biostudies-literatureUnknown8Added risk portended by diabetes in addition to hypertension has been related to an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the endothelial function compared with a placebo. However, the effect of β-blockers on the endothelial progenitor cells (EPCs) function in diabetes is still unknown. Five β-blockers (metoprolol, atenolol, propranolol, bisoprolol, and nebivolol) were tested in EPC functional screening. Metoprolol improved EPC function significantly among the five β-blockers and was chosen for the <i>in vivo</i> tests in STZ induced diabetic mice. Reactive hyperemia peripheral arterial tonometry (RH-PAT) measurements were performed using the Endo-PAT2000 device in diabetic patients. Metoprolol, but not other β-blockersPeerJMetoprolol rescues endothelial progenitor cell dysfunction in diabetes.PMC735092481703627818726602017YFC160020481803643Li JFYan LDeng YPQing TLDai XYDong YFChen JKHan XTian YJGao FYZhu JBShi WJZhang XFfalseMetoprolol rescues endothelial progenitor cell dysfunction in diabetes.Added risk portended by diabetes in addition to hypertension has been related to an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the endothelial function compared with a placebo. However, the effect of β-blockers on the endothelial progenitor cells (EPCs) function in diabetes is still unknown. Five β-blockers (metoprolol, atenolol, propranolol, bisoprolol, and nebivolol) were tested in EPC functional screening. Metoprolol improved EPC function significantly among the five β-blockers and was chosen for the <i>in vivo</i> tests in STZ induced diabetic mice. Reactive hyperemia peripheral arterial tonometry (RH-PAT) measurements were performed using the Endo-PAT2000 device in diabetic patients. Metoprolol, but not other β-blockers2020-01-01T00:00:00Z20202025-04-19T21:09:28.214Z2025-02-19T00:51:41.389ZS-EPMC73509243270443810.7717/peerj.9306