biostudies-literatureHwang JPNCI NIH HHS959-967https://www.ebi.ac.uk/biostudies/studies/S-EPMC7351320biostudies-literatureUnknown36(10)<h4>Purpose</h4>Most patients with cancer are not screened for hepatitis B virus (HBV) infection before undergoing anticancer therapy, and optimal screening strategies are unknown. We sought to develop selective HBV screening strategies for patients who require systemic anticancer therapy.<h4>Methods</h4>This prospective cohort study included adults age ≥ 18 years with solid or hematologic malignancies who received systemic anticancer therapy at a comprehensive cancer center during 2013 and 2014. Patients underwent hepatitis B surface antigen, hepatitis B core antibody, and hepatitis B surface antibody testing, and completed a 19-question modified Centers for Disease Control and Prevention (CDC) HBV survey. Multivariable models that predict chronic or past HBV infection were developed and Journal of clinical oncology : official journal of the American Society of Clinical OncologyModels to Predict Hepatitis B Virus Infection Among Patients With Cancer Undergoing Systemic Anticancer Therapy: A Prospective Cohort Study.PMC7351320K07 CA132955Granwehr BPCantor SBAhmed SRomaguera JHwang JPFisch MJVierling JMLin HYForeman JTSimon GRFerrajoli ASuarez-Almazor MELok ASBarbo ATorres HAMiller EEng CfalseModels to Predict Hepatitis B Virus Infection Among Patients With Cancer Undergoing Systemic Anticancer Therapy: A Prospective Cohort Study.<h4>Purpose</h4>Most patients with cancer are not screened for hepatitis B virus (HBV) infection before undergoing anticancer therapy, and optimal screening strategies are unknown. We sought to develop selective HBV screening strategies for patients who require systemic anticancer therapy.<h4>Methods</h4>This prospective cohort study included adults age ≥ 18 years with solid or hematologic malignancies who received systemic anticancer therapy at a comprehensive cancer center during 2013 and 2014. Patients underwent hepatitis B surface antigen, hepatitis B core antibody, and hepatitis B surface antibody testing, and completed a 19-question modified Centers for Disease Control and Prevention (CDC) HBV survey. Multivariable models that predict chronic or past HBV infection were developed and 2018-01-01T00:00:00Z2018 Apr2025-06-01T02:34:52.353Z2020-11-19T13:29:05ZS-EPMC73513202944706110.1200/JCO.2017.75.638710.1200/jco.2017.75.6387