{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20"],"submitter":["Krishnan DA"],"funding":["Indian Council of Medical Research"],"pubmed_abstract":["The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity. By analogy with earlier reports about Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) - viruses, the novel Coronavirus' replication mechanism is likely well understood. The structure of an endoribonuclease (NSP15) of SARS-CoV-2 was reported recently. This enzyme is expected to play a crucial role in replication. In this work, attempts were made to identify inhibitors of this enzyme. To achieve the goal, high throughput <i>in silico</i> screening and molecular docking procedures were performed. From an Enamine database of a billion"],"journal":["Informatics in medicine unlocked"],"pagination":["100392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7351674"],"repository":["biostudies-literature"],"pubmed_title":["Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15."],"pmcid":["PMC7351674"],"pubmed_authors":["Sangeetha G","Vajravijayan S","Gunasekaran K","Krishnan DA","Nandhagopal N"],"additional_accession":[]},"is_claimable":false,"name":"Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15.","description":"The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity. By analogy with earlier reports about Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) - viruses, the novel Coronavirus' replication mechanism is likely well understood. The structure of an endoribonuclease (NSP15) of SARS-CoV-2 was reported recently. This enzyme is expected to play a crucial role in replication. In this work, attempts were made to identify inhibitors of this enzyme. To achieve the goal, high throughput <i>in silico</i> screening and molecular docking procedures were performed. From an Enamine database of a billion","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-07T22:27:50.916Z","creation":"2020-08-29T07:19:38Z"},"accession":"S-EPMC7351674","cross_references":{"pubmed":["32835078"],"doi":["10.1016/j.imu.2020.100392"]}}