biostudies-literatureUnknown20Krishnan DAIndian Council of Medical ResearchThe world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity. By analogy with earlier reports about Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) - viruses, the novel Coronavirus' replication mechanism is likely well understood. The structure of an endoribonuclease (NSP15) of SARS-CoV-2 was reported recently. This enzyme is expected to play a crucial role in replication. In this work, attempts were made to identify inhibitors of this enzyme. To achieve the goal, high throughput <i>in silico</i> screening and molecular docking procedures were performed. From an Enamine database of a billionInformatics in medicine unlocked100392https://www.ebi.ac.uk/biostudies/studies/S-EPMC7351674biostudies-literatureStructure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15.PMC7351674Sangeetha GVajravijayan SGunasekaran KKrishnan DANandhagopal NfalseStructure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15.The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity. By analogy with earlier reports about Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) - viruses, the novel Coronavirus' replication mechanism is likely well understood. The structure of an endoribonuclease (NSP15) of SARS-CoV-2 was reported recently. This enzyme is expected to play a crucial role in replication. In this work, attempts were made to identify inhibitors of this enzyme. To achieve the goal, high throughput <i>in silico</i> screening and molecular docking procedures were performed. From an Enamine database of a billion2020-01-01T00:00:00Z20202026-04-07T22:27:50.916Z2020-08-29T07:19:38ZS-EPMC73516743283507810.1016/j.imu.2020.100392