{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Olivera-Castillo L"],"pubmed_abstract":["Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical gene"],"journal":["Nutrients"],"pagination":["E1698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7352476"],"repository":["biostudies-literature"],"pubmed_title":["A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo."],"pmcid":["PMC7352476"],"pubmed_authors":["Olivera-Castillo L","Acevedo JJ","Davalos A","Perez-Vega JA","Gil-Zamorano J","Carrillo-Cocom LM","Hernandez-Garibay E","Grant G","Kantun-Moreno N","Medina-Contreras O","Fernandez-Herrera MA","Perez-Tapia M","Olvera-Novoa MA","Puerto-Castillo C","Barrera-Perez HA","Montero J","May Solis V","Rodriguez-Canul R","Villanueva-Toledo JR"],"additional_accession":[]},"is_claimable":false,"name":"A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo.","description":"Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical gene","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-19T11:40:32.071Z","creation":"2025-04-19T11:40:32.071Z"},"accession":"S-EPMC7352476","cross_references":{"pubmed":["32517205"],"doi":["10.3390/nu12061698"]}}