biostudies-literatureUnknown12(6)Olivera-Castillo LSea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical geneNutrientsE1698https://www.ebi.ac.uk/biostudies/studies/S-EPMC7352476biostudies-literatureA Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo.PMC7352476Olivera-Castillo LAcevedo JJDavalos APerez-Vega JAGil-Zamorano JCarrillo-Cocom LMHernandez-Garibay EGrant GKantun-Moreno NMedina-Contreras OFernandez-Herrera MAPerez-Tapia MOlvera-Novoa MAPuerto-Castillo CBarrera-Perez HAMontero JMay Solis VRodriguez-Canul RVillanueva-Toledo JRfalseA Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo.Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical gene2020-01-01T00:00:00Z2020 Jun2025-04-19T11:40:32.071Z2025-04-19T11:40:32.071ZS-EPMC73524763251720510.3390/nu12061698