biostudies-literatureUnknown12(6)Le Thiec MDue to the heterogeneity of tumour mass segmentation methods and lack of consensus, our study evaluated the prognostic value of pretherapeutic positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters using different segmentation methods in patients with localized anal squamous cell carcinoma (SCC). Eighty-one patients with FDG-PET before radiochemotherapy were retrospectively analyzed. Semiquantitative data were measured with three fixed thresholds (35%, 41% and 50% of Maximum Standardized Uptake Value (SUVmax)) and four segmentation methods based on iterative approaches (Black, Adaptive, Nestle and Fitting). Metabolic volumes of primary anal tumour (P-MTV) and total tumour load (T-MTV: P-MTV+ lymph node MTV) were calculated. The primary endpoint was event-free sCancersE1512https://www.ebi.ac.uk/biostudies/studies/S-EPMC7352672biostudies-literaturePrognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer.PMC7352672Maucherat BRousseau CHamidou HRio EGuillerminet CMeyer VGCampion LHiret SLe Thiec MTestard AMorel OGirault SRusu DFerrer LKraeber-Bodere FLacombe MfalsePrognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer.Due to the heterogeneity of tumour mass segmentation methods and lack of consensus, our study evaluated the prognostic value of pretherapeutic positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters using different segmentation methods in patients with localized anal squamous cell carcinoma (SCC). Eighty-one patients with FDG-PET before radiochemotherapy were retrospectively analyzed. Semiquantitative data were measured with three fixed thresholds (35%, 41% and 50% of Maximum Standardized Uptake Value (SUVmax)) and four segmentation methods based on iterative approaches (Black, Adaptive, Nestle and Fitting). Metabolic volumes of primary anal tumour (P-MTV) and total tumour load (T-MTV: P-MTV+ lymph node MTV) were calculated. The primary endpoint was event-free s2020-01-01T00:00:00Z2020 Jun2025-04-26T08:12:06.191Z2025-04-06T12:38:49.175ZS-EPMC73526723252703910.3390/cancers12061512