{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(12)"],"submitter":["Do J"],"pubmed_abstract":["Abnormal amyloid-β (Aβ) accumulation is the most significant feature of Alzheimer's disease (AD). Among the several secretases involved in the generation of Aβ, β-secretase (BACE1) is the first rate-limiting enzyme in Aβ production that can be utilized to prevent the development of Aβ-related pathologies. Cinnamon extract, used in traditional medicine, was shown to inhibit the aggregation of tau protein and Aβ aggregation. However, the effect of trans-cinnamaldehyde (TCA), the main component of cinnamon, on Aβ deposition is unknown. Five-month-old 5XFAD mice were treated with TCA for eight weeks. Seven-month-old 5XFAD mice were evaluated for cognitive and spatial memory function. Brain samples collected at the conclusion of the treatment were assessed by immunofluorescence and biochemical "],"journal":["International journal of molecular sciences"],"pagination":["E4492"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7352815"],"repository":["biostudies-literature"],"pubmed_title":["Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice."],"pmcid":["PMC7352815"],"pubmed_authors":["Oh MS","Do J","Lee JK","Gee MS","Kim JH","Jeon SH","Ju YJ","Kim N"],"additional_accession":[]},"is_claimable":false,"name":"Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice.","description":"Abnormal amyloid-β (Aβ) accumulation is the most significant feature of Alzheimer's disease (AD). Among the several secretases involved in the generation of Aβ, β-secretase (BACE1) is the first rate-limiting enzyme in Aβ production that can be utilized to prevent the development of Aβ-related pathologies. Cinnamon extract, used in traditional medicine, was shown to inhibit the aggregation of tau protein and Aβ aggregation. However, the effect of trans-cinnamaldehyde (TCA), the main component of cinnamon, on Aβ deposition is unknown. Five-month-old 5XFAD mice were treated with TCA for eight weeks. Seven-month-old 5XFAD mice were evaluated for cognitive and spatial memory function. Brain samples collected at the conclusion of the treatment were assessed by immunofluorescence and biochemical ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-19T11:40:39.191Z","creation":"2025-04-19T11:40:39.191Z"},"accession":"S-EPMC7352815","cross_references":{"pubmed":["32599846"],"doi":["10.3390/ijms21124492"]}}