biostudies-literatureFeola SHelsinki Institute of Life ScienceHorizon 2020 Framework ProgrammeE1660https://www.ebi.ac.uk/biostudies/studies/S-EPMC7352969biostudies-literatureUnknown12(6)According to the latest available data, cancer is the second leading cause of death, highlighting the need for novel cancer therapeutic approaches. In this context, immunotherapy is emerging as a reliable first-line treatment for many cancers, particularly metastatic melanoma. Indeed, cancer immunotherapy has attracted great interest following the recent clinical approval of antibodies targeting immune checkpoint molecules, such as PD-1, PD-L1, and CTLA-4, that release the brakes of the immune system, thus reviving a field otherwise poorly explored. Cancer immunotherapy mainly relies on the generation and stimulation of cytotoxic CD8 T lymphocytes (CTLs) within the tumor microenvironment (TME), priming T cells and establishing efficient and durable anti-tumor immunity. Therefore, there is CancersUncovering the Tumor Antigen Landscape: What to Know about the Discovery Process.PMC7352969681219noneMartins BCerullo VFeola SChiaro JfalseUncovering the Tumor Antigen Landscape: What to Know about the Discovery Process.According to the latest available data, cancer is the second leading cause of death, highlighting the need for novel cancer therapeutic approaches. In this context, immunotherapy is emerging as a reliable first-line treatment for many cancers, particularly metastatic melanoma. Indeed, cancer immunotherapy has attracted great interest following the recent clinical approval of antibodies targeting immune checkpoint molecules, such as PD-1, PD-L1, and CTLA-4, that release the brakes of the immune system, thus reviving a field otherwise poorly explored. Cancer immunotherapy mainly relies on the generation and stimulation of cytotoxic CD8 T lymphocytes (CTLs) within the tumor microenvironment (TME), priming T cells and establishing efficient and durable anti-tumor immunity. Therefore, there is 2020-01-01T00:00:00Z2020 Jun2025-06-01T02:36:01.978Z2020-11-19T16:52:18ZS-EPMC73529693258581810.3390/cancers12061660