biostudies-literatureBailly CAgence Nationale de la RechercheE1467https://www.ebi.ac.uk/biostudies/studies/S-EPMC7352991biostudies-literatureUnknown12(6)Despite constant progress over the past three decades, multiple myeloma (MM) is still an incurable disease, and the identification of new biomarkers to better select patients and adapt therapy is more relevant than ever. Recently, the introduction of therapeutic monoclonal antibodies (mAbs) (including direct-targeting mAbs and immune checkpoint inhibitors) appears to have changed the paradigm of MM management, emphasizing the opportunity to cure MM patients through an immunotherapeutic approach. In this context, immuno-positron emission tomography (immunoPET), combining the high sensitivity and resolution of a PET camera with the specificity of a radiolabelled mAb, holds the capability to cement this new treatment paradigm for MM patients. It has the potential to non-invasively monitor theCancersImmunoPET in Multiple Myeloma-What? So What? Now What?PMC7352991ANR-11-LABX-0016-01ANR-11-LABX-0018-01ANR-11-EQPX-0004Touzeau CCherel MGouard SBodet-Milin CChalopin BCarlier TBailly CMarionneau-Lambot SMoreau PSaec PRKraeber-Bodere FfalseImmunoPET in Multiple Myeloma-What? So What? Now What?Despite constant progress over the past three decades, multiple myeloma (MM) is still an incurable disease, and the identification of new biomarkers to better select patients and adapt therapy is more relevant than ever. Recently, the introduction of therapeutic monoclonal antibodies (mAbs) (including direct-targeting mAbs and immune checkpoint inhibitors) appears to have changed the paradigm of MM management, emphasizing the opportunity to cure MM patients through an immunotherapeutic approach. In this context, immuno-positron emission tomography (immunoPET), combining the high sensitivity and resolution of a PET camera with the specificity of a radiolabelled mAb, holds the capability to cement this new treatment paradigm for MM patients. It has the potential to non-invasively monitor the2020-01-01T00:00:00Z2020 Jun2025-04-04T22:34:01.214Z2025-02-19T03:23:56.077ZS-EPMC73529913251288310.3390/cancers12061467